Title:
COMPOSITION FOR TREATING DIABETES, CONTAINING LONG-ACTING INSULIN ANALOG CONJUGATE AND LONG-ACTING INSULIN SECRETION PEPTIDE CONJUGATE
Document Type and Number:
WIPO Patent Application WO/2015/183038
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating diabetes, containing long-acting insulin analog and long-acting insulin secretion peptide conjugates, and a method for treating diabetes. More specifically, the composition can remarkably improve compliance by inhibiting weight gain caused by the administration of insulin, inhibiting emesis and nausea phenomena caused by the administration of an insulin secretion peptide and reducing the dose of insulin through the concomitant administration of the long-acting analog conjugate and the long-acting insulin secretion peptide conjugate. In addition, the present invention relates to: a pharmaceutical composition for alleviating the side effects of pancreatic beta cells in a patient with diabetes, containing a long-acting insulin analog conjugate and a long-acting insulin secretion peptide conjugate; and a method for alleviating the side effects of pancreatic beta cells in a patient with diabetes, comprising a step of administering the composition, wherein side effects, particularly those such as pancreatic beta cell dysfunction, pancreatic beta cell reduction, lipotoxicity and glucotoxicity, which are caused by the progression of diabetes, are alleviated.
Inventors:
KIM JUNG KUK (KR)
KIM DAE JIN (KR)
HEO YONG HO (KR)
CHOI IN YOUNG (KR)
JUNG SUNG YOUB (KR)
KWON SE CHANG (KR)
KIM DAE JIN (KR)
HEO YONG HO (KR)
CHOI IN YOUNG (KR)
JUNG SUNG YOUB (KR)
KWON SE CHANG (KR)
Application Number:
PCT/KR2015/005424
Publication Date:
December 03, 2015
Filing Date:
May 29, 2015
Export Citation:
Assignee:
HANMI PHARM IND CO LTD (KR)
International Classes:
A61K38/28; A61K38/26; A61K47/30; A61K47/48
Foreign References:
| KR20120135123A | 2012-12-12 | |||
| KR20110084956A | 2011-07-26 | |||
| JP2012229214A | 2012-11-22 | |||
| KR20110092253A | 2011-08-17 | |||
| KR20110137819A | 2011-12-23 |
Other References:
See also references of EP 3156066A4
Attorney, Agent or Firm:
SON, MIN (KR)
손민 (KR)
손민 (KR)
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