Title:
COMPOSITION FOR TREATING DIABETES MELLITUS COMPRISING INSULIN AND A GLP-1/GLUCAGON DUAL AGONIST
Document Type and Number:
WIPO Patent Application WO/2015/183054
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating diabetes mellitus comprising insulin and a GLP-1/glucagon dual agonist, and a method for preventing or treating diabetes mellitus. More specifically, the present composition can inhibit the weight gain and reduce the danger of hypoglycemia due to the administration of insulin, lower the administration dose and greatly improve the compliance of drugs through a combined administration of a long-acting insulin conjugate and a long-acting GLP-1/glucagon dual agonist conjugate. In addition, the long-acting insulin conjugate and the long-acting GLP-1/glucagon dual agonist conjugate according to the present invention can improve the in vivo sustainability and stability because an insulin and a GLP-1/glucagon dual agonist are linked to the immunoglobulin Fc region via a non-peptidyl linker.
More Like This:
Inventors:
JUNG SUNG YOUB (KR)
HWANG SANG YOUN (KR)
KIM SEUNG SU (KR)
CHOI IN YOUNG (KR)
KWON SE CHANG (KR)
HWANG SANG YOUN (KR)
KIM SEUNG SU (KR)
CHOI IN YOUNG (KR)
KWON SE CHANG (KR)
Application Number:
PCT/KR2015/005455
Publication Date:
December 03, 2015
Filing Date:
June 01, 2015
Export Citation:
Assignee:
HANMI PHARM IND CO LTD (KR)
International Classes:
A61K38/28; A61K38/26; A61P3/00; A61P3/10
Domestic Patent References:
| WO2012169798A2 | 2012-12-13 | |||
| WO2013110069A1 | 2013-07-25 | |||
| WO2014049610A2 | 2014-04-03 | |||
| WO2012169798A2 | 2012-12-13 | |||
| WO2012165915A2 | 2012-12-06 | |||
| WO2014017847A1 | 2014-01-30 | |||
| WO2014017849A1 | 2014-01-30 | |||
| WO2012173422A1 | 2012-12-20 | |||
| WO2014017843A1 | 2014-01-30 | |||
| WO2014073845A1 | 2014-05-15 | |||
| WO2014073842A1 | 2014-05-15 | |||
| WO1997034631A1 | 1997-09-25 | |||
| WO1996032478A1 | 1996-10-17 |
Foreign References:
| KR101058290B1 | 2011-08-22 | |||
| US5175145A | 1992-12-29 | |||
| US20050288248A1 | 2005-12-29 | |||
| KR100725315B1 | 2007-06-07 | |||
| KR101058290B1 | 2011-08-22 | |||
| KR20140022909A | 2014-02-25 | |||
| KR20120139579A | 2012-12-27 | |||
| EP2017288A1 | 2009-01-21 | |||
| KR20140006938A | 2014-01-16 | |||
| KR20120137271A | 2012-12-20 | |||
| KR101330868B1 | 2013-11-18 | |||
| KR101324828B1 | 2013-11-01 | |||
| KR20110111267A | 2011-10-10 |
Other References:
LORENZ ET AL.: "Recent progress and future options in the development of GLP-1 receptor agonists for the treatment of diabesity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, no. 14, 2013, pages 4011 - 4018, XP028573319, ISSN: 0960-894x
FOSGERAU ET AL.: "combination of long-acting insulin with the dual GluGLP-1 agonist ZP2929", DIABETES, 2011
H. NEURATHR. L. HILL: "The Proteins", 1979, ACADEMIC PRESS
See also references of EP 3148571A4
FOSGERAU ET AL.: "combination of long-acting insulin with the dual GluGLP-1 agonist ZP2929", DIABETES, 2011
H. NEURATHR. L. HILL: "The Proteins", 1979, ACADEMIC PRESS
See also references of EP 3148571A4
Attorney, Agent or Firm:
SON, Min (STX R&D Center 6th Floor, 163, YangJaeCheon-ro,,Gangnam-gu, Seoul 135-855, KR)
Download PDF: