Title:
COMPOSITION FOR TREATING HIV INFECTION
Document Type and Number:
WIPO Patent Application WO/2024/048792
Kind Code:
A1
Abstract:
The present disclosure provides a composition for treating viral infections. In one mode, the present disclosure provides a composition that is for treating viral infections in subjects, and that includes a nucleic acid construct having, in an activatable manner, a nucleotide sequence encoding Ag85B protein and a nucleotide sequence encoding an antigen protein included in a virus belonging to the genus Lintivirus or a portion of the protein. In one embodiment, the composition according to the present disclosure is characterized by being administered after a viral infection.
Inventors:
YASUTOMI YASUHIRO (JP)
OKAMURA TOMOTAKA (JP)
OKAMURA TOMOTAKA (JP)
Application Number:
PCT/JP2023/032141
Publication Date:
March 07, 2024
Filing Date:
September 01, 2023
Export Citation:
Assignee:
NAT INST BIOMEDICAL INNOVATION HEALTH & NUTRITION (JP)
International Classes:
A61K48/00; A61K45/00; A61P31/12; A61P31/18; A61P43/00; C07K14/155; C12N15/31; C12N15/49
Other References:
YASUTOMI, YASUHIRO: "Long-term sterile immunity induced by an adjuvant-containing live-attenuated AIDS virus", THE JOURNAL OF IMMUNOLOGY, vol. 208, no. 1_Suppl., 1 May 2022 (2022-05-01), US , pages 64.16, XP009553526, ISSN: 0022-1767, DOI: 10.4049/jimmunol.208.Supp.64.16
OKAMURA TOMOTAKA, SHIMIZU YUYA, ASAKA MASAMITSU N., KANUMA TOMOHIRO, TSUJIMURA YUSUKE, YAMAMOTO TAKUYA, MATSUO KAZUHIRO, YASUTOMI : "Long-term protective immunity induced by an adjuvant-containing live-attenuated AIDS virus", NPJ VACCINES, NATURE PUBLISHING GROUP, vol. 6, no. 1, 1 January 2021 (2021-01-01), pages 124, XP093143337, ISSN: 2059-0105, DOI: 10.1038/s41541-021-00386-5
OKAMURA TOMOTAKA, YASUTOMI YASUHIRO: "Long-term sterile immunity induced by an adjuvant-containing live-attenuated AIDS virus", JOURNAL OF MEDICAL PRIMATOLOGY, WILEY-BLACKWELL PUBLISHING, US, vol. 49, no. 5, 1 October 2020 (2020-10-01), US , pages 267, XP093143345, ISSN: 0047-2565, DOI: 10.1111/jmp.12489
唐松克夫ほか, Ｔｈ１誘導効果をもつアジュバントとしての抗酸菌分泌抗原Ａｇ８５Ｂ, 臨床免疫・アレルギー科, 2006, vol. 46, no. 6, pp. 653-658
岡村智崇ほか, 抗酸菌分泌抗原を組み込んだ弱毒エイズウイルスの霊長類カニクイザルにおける細胞性免疫反応の解析, 第６１回日本ウイルス学会学術集会プログラム・抄録集, 2013, vol. 61, p. 246
岡村智崇ほか, 強力な細胞性免疫を誘導するＡｇ８５Ｂ発現弱毒エイズウイルスの防御免疫機構の解析, 第６０回日本ウイルス学会学術集会プログラム・抄録集, 2012, vol. 60, p. 342
岡村智崇ほか, アジュバント分子Ａｇ８５Ｂを組み込んだエイズウイルスの霊長類エイズモデルでの制御, 第２５回日本ワクチン学会学術集会プログラム・抄録集, 2021, vol. 25, p. 136, 12-1 (poster no. P-68)
保富康宏ほか, サルエイズモデルを用いたアジュバント遺伝子組み込みエイズウイルスに関する研究, 厚生労働科学研究費補助金 エイズ対策研究事業 ＨＩＶの感染防止、ＡＩＤＳ発症防止に関する疫学的基礎研究 平成２２年度 総括・分担研究報告書, 2011, pp. 45-53 abstract, p. 47, left column, 2nd paragraph, (YASUTOMI, Yasuhiro et al.), non-official translation (Research on adjuvant gene-integrated AIDS virus using monkey AIDS model. Health, Labor and Welfare Scientific Research Grant. Research project against AIDS: Basic epidemiological research on preventing HIV infection and preventing the spread of AIDS. 2010 Research report on generalization and allotment.)
OKAMURA TOMOTAKA, YASUHIRO YASUTOMI: "Research on curing AIDS,", UIRUSU, vol. 72, no. 2, 1 December 2022 (2022-12-01), pages 167 - 170, XP093145570, ISSN: 1884-3433, DOI: 10.2222/jsv.72.167
OKAMURA TOMOTAKA, SHIMIZU YUYA, ASAKA MASAMITSU N., KANUMA TOMOHIRO, TSUJIMURA YUSUKE, YAMAMOTO TAKUYA, MATSUO KAZUHIRO, YASUTOMI : "Long-term protective immunity induced by an adjuvant-containing live-attenuated AIDS virus", NPJ VACCINES, NATURE PUBLISHING GROUP, vol. 6, no. 1, 1 January 2021 (2021-01-01), pages 124, XP093143337, ISSN: 2059-0105, DOI: 10.1038/s41541-021-00386-5
OKAMURA TOMOTAKA, YASUTOMI YASUHIRO: "Long-term sterile immunity induced by an adjuvant-containing live-attenuated AIDS virus", JOURNAL OF MEDICAL PRIMATOLOGY, WILEY-BLACKWELL PUBLISHING, US, vol. 49, no. 5, 1 October 2020 (2020-10-01), US , pages 267, XP093143345, ISSN: 0047-2565, DOI: 10.1111/jmp.12489
唐松克夫ほか, Ｔｈ１誘導効果をもつアジュバントとしての抗酸菌分泌抗原Ａｇ８５Ｂ, 臨床免疫・アレルギー科, 2006, vol. 46, no. 6, pp. 653-658
岡村智崇ほか, 抗酸菌分泌抗原を組み込んだ弱毒エイズウイルスの霊長類カニクイザルにおける細胞性免疫反応の解析, 第６１回日本ウイルス学会学術集会プログラム・抄録集, 2013, vol. 61, p. 246
岡村智崇ほか, 強力な細胞性免疫を誘導するＡｇ８５Ｂ発現弱毒エイズウイルスの防御免疫機構の解析, 第６０回日本ウイルス学会学術集会プログラム・抄録集, 2012, vol. 60, p. 342
岡村智崇ほか, アジュバント分子Ａｇ８５Ｂを組み込んだエイズウイルスの霊長類エイズモデルでの制御, 第２５回日本ワクチン学会学術集会プログラム・抄録集, 2021, vol. 25, p. 136, 12-1 (poster no. P-68)
保富康宏ほか, サルエイズモデルを用いたアジュバント遺伝子組み込みエイズウイルスに関する研究, 厚生労働科学研究費補助金 エイズ対策研究事業 ＨＩＶの感染防止、ＡＩＤＳ発症防止に関する疫学的基礎研究 平成２２年度 総括・分担研究報告書, 2011, pp. 45-53 abstract, p. 47, left column, 2nd paragraph, (YASUTOMI, Yasuhiro et al.), non-official translation (Research on adjuvant gene-integrated AIDS virus using monkey AIDS model. Health, Labor and Welfare Scientific Research Grant. Research project against AIDS: Basic epidemiological research on preventing HIV infection and preventing the spread of AIDS. 2010 Research report on generalization and allotment.)
OKAMURA TOMOTAKA, YASUHIRO YASUTOMI: "Research on curing AIDS,", UIRUSU, vol. 72, no. 2, 1 December 2022 (2022-12-01), pages 167 - 170, XP093145570, ISSN: 1884-3433, DOI: 10.2222/jsv.72.167
Attorney, Agent or Firm:
KAMADA, Mitsunori et al. (JP)
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