COMPOSITION FOR TREATING INFLAMMATORY BRAIN DISEASE COMPRISING STEM-CELL-DERIVED EXOSOME AS AN ACTIVE INGREDIENT

Title:

COMPOSITION FOR TREATING INFLAMMATORY BRAIN DISEASE COMPRISING STEM-CELL-DERIVED EXOSOME AS AN ACTIVE INGREDIENT

Document Type and Number:

WIPO Patent Application WO/2015/142061

Kind Code:

A1

Abstract:

The present invention relates to a composition for treating inflammatory brain disease comprising stem-cell-derived exosome as an active ingredient. The stem-cell-derived exosome according to the present invention can advantageously be used in the treatment of inflammatory brain disease, since the exosome has outstanding therapeutic effects including suppressing cell death due to inflammation in nerve cells, and, in an inflammatory-brain-disease animal model, increasing survival rates, and markedly reducing brain damage and the inflammatory cytokine count due to inflammatory reactions such as oedema.

Inventors:

CHANG YUN SIL (KR)
PARK WON SOON (KR)
SUNG DONG KYUNG (KR)
AHN SO YOON (KR)

Application Number:

PCT/KR2015/002640

Publication Date:

September 24, 2015

Filing Date:

March 18, 2015

Export Citation:

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Assignee:

SAMSUNG LIFE PUBLIC WELFARE FOUNDATION (KR)

International Classes:

A61K35/54; A61K35/12; A61P25/00; A61P29/00

Domestic Patent References:

WO2014013029A1

2014-01-23

Foreign References:

KR20100081003A	2010-07-14
US20130195899A1	2013-08-01

Other References:

KIM, S. H. ET AL.: "Effective Treatment of inflammatory disease models with exosomes derived from dendritic cells genetically modified to express IL -4", THE JOURNAL OF IMMUNOLOGY, vol. 179, no. 4, 2007, pages 2242 - 2249, XP055358624
XIN, H. ET AL.: "Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats", JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM, vol. 33, 2013, pages 1711 - 1715, XP055226654

Attorney, Agent or Firm:

KIM, SOON WOONG (KR)
김순웅 (KR)

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