COMPOSITION FOR TREATING NEONATAL HIE - SAMSUNG LIFE PUBLIC WELFARE FOUNDATION

Title:

COMPOSITION FOR TREATING NEONATAL HIE

Document Type and Number:

WIPO Patent Application WO/2018/131779

Kind Code:

A1

Abstract:

The present invention relates to a pharmaceutical composition for preventing or treating neonatal hypoxic ischemic encephalopathy (HIE), comprising a thrombin-treated stem cell or an exosome derived therefrom as an active ingredient, and a method for producing the same. According to the present invention, the thrombin-treated stem cell or the exosome derived therefrom has an increased expression of growth factors, immunoregulatory factors, antioxidant factors, or regeneration factors compared to a group not treated with thrombin and also enhances a neuronal apoptosis inhibitory effect, and thus has an advantage in that the therapeutic effect thereof on neonatal hypoxic ischemic encephalopathy (HIE) is excellent.

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Inventors:

CHANG YUN SIL (KR)
PARK WON SOON (KR)
AHN SO YOON (KR)
SUNG DONG KYUNG (KR)

Application Number:

PCT/KR2017/012119

Publication Date:

July 19, 2018

Filing Date:

October 31, 2017

Export Citation:

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Assignee:

SAMSUNG LIFE PUBLIC WELFARE FOUNDATION (KR)

International Classes:

A61K35/28; A61K9/00; A61K9/12; A61K35/50; A61K35/51; A61K35/545; A61K38/48

Domestic Patent References:

WO2015179227A1

2015-11-26

Foreign References:

KR20160078946A	2016-07-05
KR101661847B1	2016-09-30
KR20170099382A	2017-08-31

Other References:

MITSIALIS, S. A. ET AL.: "Stem Cell -based Therapies for the Newborn Lung and Brain: Possibilities and Challenges", SEMIN. PERINATOL., vol. 40, no. 3, April 2016 (2016-04-01), pages 138 - 151, XP029470512
GONZALES-PORTILLO, G. S. ET AL.: "Stem Cell Therapy for Neonatal Hypoxic-ischemic Encephalopathy", FRONTIERS IN NEUROLOGY, vol. 5, 12 August 2014 (2014-08-12), pages 1 - 10, XP055513845
See also references of EP 3569238A4

Attorney, Agent or Firm:

ISIS IP LAW LLC (KR)

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