Title:
COMPOSITION FOR TREATING OR PREVENTING ATOPIC DERMATITIS
Document Type and Number:
WIPO Patent Application WO/2019/230230
Kind Code:
A1
Abstract:
The present specification provides a composition for treating or preventing atopic dermatitis. The present invention provides a composition for treating or preventing atopic dermatitis, the composition containing a β-adrenergic receptor agonist. In one embodiment, the β-adrenergic receptor agonist is selected from the group consisting of a selective β1-adrenergic receptor agonist, a selective β2-adrenergic receptor agonist, a selective β3-adrenergic receptor agonist, and a non-selective β-adrenergic receptor agonist, but the β-adrenergic receptor agonist is preferably a selective β2-adrenergic receptor agonist or a non-selective β-adrenergic receptor agonist.
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Inventors:
KUBOTA YOSHIKI (JP)
NAGASAWA TERUAKI (JP)
ARAI MINA (JP)
NAGASAWA NANAKO (JP)
YAMAGUCHI YOKO (JP)
NAGASAWA TERUAKI (JP)
ARAI MINA (JP)
NAGASAWA NANAKO (JP)
YAMAGUCHI YOKO (JP)
Application Number:
PCT/JP2019/016305
Publication Date:
December 05, 2019
Filing Date:
April 16, 2019
Export Citation:
Assignee:
NANOEGG RES LABORATORIES INC (JP)
International Classes:
A61K45/00; A61K31/137; A61K31/138; A61K31/167; A61K31/196; A61K31/216; A61K31/24; A61K31/27; A61K31/36; A61K31/426; A61K31/44; A61K31/4704; A61K31/472; A61K31/5375; A61K31/538; A61P17/00; A61P37/08; G01N33/15; G01N33/50
Foreign References:
| JP2000503628A | 2000-03-28 | |||
| JP2017507930A | 2017-03-23 |
Other References:
GROENNEBERG R: "Inhibition of allergen-induced early reactions in atopic skin by salbutamol and theophylline", AGENTS AND ACTIONS, vol. 16, no. 6, 1985, pages 501 - 503, ISSN: 0065-4299
ARCHER C.B. ET AL.: "Actions of locally administered adrenoceptor agonists on histamine-induced cutaneous responses in atopic eczema", CLIN EXP DERMATOL ., vol. 9, no. 4, 1984, pages 358 - 363, XP000989906, ISSN: 0307-6938
KONDO N. ET AL.: "Inhibition of interferon-gamma production from lymphocytes stimulated with food antigens by a beta 2-agonist, procaterol, in patients with food-sensitive atopic dermatitis", J INVEST ALLERGOL CLIN IMMUNOL., vol. 7, no. 4, 1997, pages 225 - 228, XP008008273, ISSN: 1018-9068
HAZAMAY ET AL.: "Preclinical Study of Tacrolimus Ointment for Prevention of Its Systemic Absorption in Atopic Dermatitis Model Mice According to Their Skin Conditions", JPN J PHARM HEALTH CARE SCI., vol. 43, no. 9, 2017, pages 477 - 491, XP055662690, ISSN: 1346-342X
YAMAMOTO, SHOSO ET AL.,: "Development of disease model animal of atopic dermatitis, srudy on the role of mast cells and exacerbation factors in this disease", INTEGRATED RESEARCH BUSINESS FOR MINISTRY OF HEALTH AND WELFARE LONG-TERM CHRONIC DISEASE, 1996, pages 90 - 92
ZHANG Z ET AL.: "Up-regulated expression of substance P in CD 8+ T cells and NK1R on monocytes of atopic dermatitis", J TRANSL MED., vol. 15, 93, 2017, pages 1 - 17, XP055662701
YANO, CHIZUKO ET AL.,: "Substance P", NIPPON RINSHO, vol. 68, no. 7, 2010, pages 547 - 550, ISSN: 0047-1852
PAVLOVIC S. ET AL.: "Further exploring the brain-skin connection: stress worsens dermatitis via substance P-dependent neurogenic inflammation in mice", J INVEST DERMATOL., vol. 128, no. 2, 2008, pages 434 - 446, XP055662707
ARCHER C.B. ET AL.: "Actions of locally administered adrenoceptor agonists on histamine-induced cutaneous responses in atopic eczema", CLIN EXP DERMATOL ., vol. 9, no. 4, 1984, pages 358 - 363, XP000989906, ISSN: 0307-6938
KONDO N. ET AL.: "Inhibition of interferon-gamma production from lymphocytes stimulated with food antigens by a beta 2-agonist, procaterol, in patients with food-sensitive atopic dermatitis", J INVEST ALLERGOL CLIN IMMUNOL., vol. 7, no. 4, 1997, pages 225 - 228, XP008008273, ISSN: 1018-9068
HAZAMAY ET AL.: "Preclinical Study of Tacrolimus Ointment for Prevention of Its Systemic Absorption in Atopic Dermatitis Model Mice According to Their Skin Conditions", JPN J PHARM HEALTH CARE SCI., vol. 43, no. 9, 2017, pages 477 - 491, XP055662690, ISSN: 1346-342X
YAMAMOTO, SHOSO ET AL.,: "Development of disease model animal of atopic dermatitis, srudy on the role of mast cells and exacerbation factors in this disease", INTEGRATED RESEARCH BUSINESS FOR MINISTRY OF HEALTH AND WELFARE LONG-TERM CHRONIC DISEASE, 1996, pages 90 - 92
ZHANG Z ET AL.: "Up-regulated expression of substance P in CD 8+ T cells and NK1R on monocytes of atopic dermatitis", J TRANSL MED., vol. 15, 93, 2017, pages 1 - 17, XP055662701
YANO, CHIZUKO ET AL.,: "Substance P", NIPPON RINSHO, vol. 68, no. 7, 2010, pages 547 - 550, ISSN: 0047-1852
PAVLOVIC S. ET AL.: "Further exploring the brain-skin connection: stress worsens dermatitis via substance P-dependent neurogenic inflammation in mice", J INVEST DERMATOL., vol. 128, no. 2, 2008, pages 434 - 446, XP055662707
Attorney, Agent or Firm:
YAMAMOTO Shusaku et al. (JP)
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