COMPOSITION FOR TREATING OR PREVENTING BONE DISEASES, COMPRISING HALOFUGINONE AS ACTIVE INGREDIENT - CATHOLIC UNIV KOREA INDUSTRY ACADEMIC COOPERATION FOUNDATION

Title:

COMPOSITION FOR TREATING OR PREVENTING BONE DISEASES, COMPRISING HALOFUGINONE AS ACTIVE INGREDIENT

Document Type and Number:

WIPO Patent Application WO/2015/034330

Kind Code:

A1

Abstract:

The present invention relates to a composition for treating or preventing bone diseases, comprising halofuginone as an active ingredient and, more specifically, to a composition for treating or preventing bone diseases, comprising, as an active ingredient, halofuginone having an osteoclast differentiation inhibitory efficacy and an osteoblast differentiation stimulatory activity. The composition for treating or preventing bone diseases, comprising halofuginone as an active ingredient, according to the present invention, reduces the expression of Th17 cells and increases the expression of Treg cells, thereby representing an effect of inhibiting osteoclast differentiation and being capable of also effectively inhibiting bone resorption by osteoclast. Furthermore, the composition of the present invention will be able to be usefully utilized as a use for treatment or prevention of bone diseases by being able to promote the differentiation and activity of osteoblast.

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Inventors:

PARK SUNG-HWAN (KR)
CHO MI-LA (KR)
PARK MI-KYUNG (KR)
KWOK SEUNG-KI (KR)
LEE JENNIFER (KR)
PARK JIN-SIL (KR)
KIM SUNG-MIN (KR)
LIM MI-AE (KR)
BAEK SEUNG-YE (KR)
LEE DONG-GUN (KR)
PARK EUN-MI (KR)

Application Number:

PCT/KR2014/008426

Publication Date:

March 12, 2015

Filing Date:

September 05, 2014

Export Citation:

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Assignee:

CATHOLIC UNIV KOREA INDUSTRY ACADEMIC COOPERATION FOUNDATION (KR)

International Classes:

A61K31/517; A61P19/00; A61P19/10

Domestic Patent References:

WO2010019210A2

2010-02-18

Foreign References:

US20110311519A1	2011-12-22
US6028075A	2000-02-22
US20130164284A1	2013-06-27
US20070010538A1	2007-01-11

Attorney, Agent or Firm:

BAE, KIM & LEE IP GROUP (KR)
특허법인 태평양 (KR)

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