Title:
COMPOSITION FOR TREATING OR PREVENTING IMMUNOLOGICAL ABNORMAL INFLAMMATORY DISEASES
Document Type and Number:
WIPO Patent Application WO/2023/042555
Kind Code:
A1
Abstract:
The present disclosure provides an excellent pharmaceutical composition for treating or preventing immunological abnormal inflammatory diseases. The present disclosure provides a composition for preventing or treating immunological abnormal inflammatory diseases, said composition containing a regulator of CXCL13, CXCR5, and/or peripheral helper T cells (Tph cells) [CXCL13／CXCR5／Tph]. The present disclosure also provides: a model animal for an immunological abnormal inflammatory disease represented by Castleman's disease or the like; and a method for producing same.
Inventors:
YOSHIZAKI KAZUYUKI (JP)
KIKUSHIGE YOSHIKANE (JP)
NIIRO HIROAKI (JP)
HARADA TAKUYA (JP)
AKASHI KOICHI (JP)
KIKUSHIGE YOSHIKANE (JP)
NIIRO HIROAKI (JP)
HARADA TAKUYA (JP)
AKASHI KOICHI (JP)
Application Number:
PCT/JP2022/029363
Publication Date:
March 23, 2023
Filing Date:
July 29, 2022
Export Citation:
Assignee:
YOSHIZAKI KAZUYUKI (JP)
International Classes:
A61K39/395; A01K67/00; A61K45/00; A61P29/00; A61P37/06
Domestic Patent References:
| WO2022104384A1 | 2022-05-19 |
Foreign References:
| JP2010519280A | 2010-06-03 | |||
| JP2010530847A | 2010-09-16 | |||
| JP2016501837A | 2016-01-21 |
Other References:
DEISSEROTH ALBERT, KO CHIA-WEN, NIE LEI, ZIRKELBACH JEANNE F., ZHAO LIANG, BULLOCK JULIE, MEHROTRA NITIN, DEL VALLE PEDRO, SABER H: "FDA Approval: Siltuximab for the Treatment of Patients with Multicentric Castleman Disease", CLINICAL CANCER RESEARCH, ASSOCIATION FOR CANCER RESEARCH, US, vol. 21, no. 5, 1 March 2015 (2015-03-01), US, pages 950 - 954, XP093048155, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-14-1678
SHEILA K. PIERSON; AARON J. STONESTROM; DUSTIN SHILLING; JASON RUTH; CHRISTOPHER S. NABEL; AMRIT SINGH; YUE REN; KATIE STONE; HONG: "Plasma proteomics identifies a ‘chemokine storm’ in idiopathic multicentric Castleman disease", AMERICAN JOURNAL OF HEMATOLOGY, NEW YORK, NY, US, vol. 93, no. 7, 16 May 2018 (2018-05-16), US , pages 902 - 912, XP071631773, ISSN: 0361-8609, DOI: 10.1002/ajh.25123
SHEILA K. PIERSON; AARON J. STONESTROM; DUSTIN SHILLING; JASON RUTH; CHRISTOPHER S. NABEL; AMRIT SINGH; YUE REN; KATIE STONE; HONG: "Plasma proteomics identifies a ‘chemokine storm’ in idiopathic multicentric Castleman disease", AMERICAN JOURNAL OF HEMATOLOGY, NEW YORK, NY, US, vol. 93, no. 7, 16 May 2018 (2018-05-16), US , pages 902 - 912, XP071631773, ISSN: 0361-8609, DOI: 10.1002/ajh.25123
Attorney, Agent or Firm:
YAMAMOTO, Shusaku et al. (JP)
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