Title:
COMPOSITION FOR TREATING SOLID MALIGNANT TUMOR, AND KIT FOR TREATING SOLID MALIGNANT TUMOR
Document Type and Number:
WIPO Patent Application WO/2023/080001
Kind Code:
A1
Abstract:
Provided is a new therapeutic composition. This composition for treating a solid malignant tumor is used so as to be administered to a subject having malignant tumor cells that produce at least one inflammatory cytokine among TNFα, IL-1β, IL-5, IL-6, IL-8, IL-17, and IL-23, in combination with at least one of immature dendritic cells, and cytotoxic lymphocytes induced by dendritic cells, and contains at least one antibody that inhibits the action of the inflammatory cytokine.
Inventors:
HASUMI KENICHIRO (JP)
Application Number:
PCT/JP2022/039484
Publication Date:
May 11, 2023
Filing Date:
October 24, 2022
Export Citation:
Assignee:
HASUMI KENICHIRO (JP)
HASUMI JUN (JP)
CELL CO LTD (JP)
HASUMI JUN (JP)
CELL CO LTD (JP)
International Classes:
A61K35/15; A61K31/573; A61K35/17; A61K39/395; A61P35/00; A61P43/00; C07K16/24
Other References:
COLLIGNON AURÉLIE, SILVY FRANÇOISE, ROBERT STÉPHANE, TRAD MALIKA, GERMAIN SÉBASTIEN, NIGRI JÉRÉMY, ANDRÉ FRÉDÉRIC, RIGOT VÉRONIQUE: "Dendritic cell-based vaccination: powerful resources of immature dendritic cells against pancreatic adenocarcinoma", ONCOIMMUNOLGY, LANDES BIOSCIENCE, US, vol. 7, no. 12, 1 January 2018 (2018-01-01), US , pages e1504727, XP093063570, ISSN: 2162-4011, DOI: 10.1080/2162402X.2018.1504727
KITAMURA HIDEMITSU, OHNO YOSUKE, TOYOSHIMA YUJIRO, OHTAKE JUNYA, HOMMA SHIGENORI, KAWAMURA HIDEKI, TAKAHASHI NORIHIKO, TAKETOMI AK: "Interleukin-6/STAT3 signaling as a promising target to improve the efficacy of cancer immunotherapy", CANCER SCIENCE, JAPANESE CANCER ASSOCIATION, TOKYO, JP, vol. 108, no. 10, 1 October 2017 (2017-10-01), JP , pages 1947 - 1952, XP093063572, ISSN: 1347-9032, DOI: 10.1111/cas.13332
SATORU SHINRIKI, HIROFUMI JONO, KAZUTOSHI OTA, MITSUHARU UEDA, MAREINA KUDO, TOMOKO OTA, YUICHI OIKE, MOTOYOSHI ENDO, MUTSUKO IBUS: "Humanized Anti-Interleukin-6 Receptor Antibody Suppresses Tumor Angiogenesis and In vivo Growth of Human Oral Squamous Cell Carcinoma", CLINICAL CANCER RESEARCH, ASSOCIATION FOR CANCER RESEARCH, US, vol. 15, no. 17, 1 September 2009 (2009-09-01), US, pages 5426 - 5434, XP002628465, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-09-0287
TANAKA YASUHIRO: "Dendritic cells-based cancer vaccine — Cancer immunotherapy with tumor/dendritic cell fusions —", JOURNAL OF JAPAN SOCIETY OF IMMUNOLOGY & ALLERGOLOGY IN OTOLARYNGOLOGY (JJIAO), vol. 30, no. 1, 1 January 2012 (2012-01-01), pages 1 - 7, XP093063576
MATTHIAS PEIPER; TAKEO SATO; THOMAS STREICHERT; CLAUS FERDINAND EISENBERGER; WOLFRAM TRUDO KNOEFEL; JAKOB ROBERT IZBICKI: "Cytotoxic T lymphocyte mediated recognition of human pancreatic cancer cells", INTERNATIONAL JOURNAL OF CANCER, JOHN WILEY & SONS, INC., US, vol. 99, no. 1, 25 February 2002 (2002-02-25), US , pages 88 - 92, XP071281472, ISSN: 0020-7136, DOI: 10.1002/ijc.10280
SHIMIZU KOICHI; KOTERA YOSHIHITO; ARUGA ATSUSHI; TAKESHITA NOBUHIRO; KATAGIRI SATOSHI; ARIIZUMI SHUN-ICHI; TAKAHASHI YUTAKA; YOSHI: "Postoperative dendritic cell vaccine plus activated T-cell transfer improves the survival of patients with invasive hepatocellular carcinoma", HUMAN VACCINES & IMMUNOTHERAPEUTICS, TAYLOR & FRANCIS, US, vol. 10, no. 4, 31 March 2014 (2014-03-31), US , pages 970 - 976, XP009534152, ISSN: 2164-5515, DOI: 10.4161/hv.27678
R. ZAYNAGETDINOV, T. P. SHERRILL, L. A. GLEAVES, A. G. MCLOED, J. A. SAXON, A. C. HABERMANN, L. CONNELLY, D. DULEK, R. S. PEEBLES,: "Interleukin-5 Facilitates Lung Metastasis by Modulating the Immune Microenvironment", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 75, no. 8, 15 April 2015 (2015-04-15), US, pages 1624 - 1634, XP055560684, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-14-2379
YAO YE; YAO QING-YU; XUE JUN-SHENG; TIAN XIU-YUN; AN QI-MING; CUI LI-XUAN; XU CHANG; SU HONG; YANG LIANG; FENG YAO-YAO; HAO CHUN-Y: "Dexamethasone inhibits pancreatic tumor growth in preclinical models: Involvement of activating glucocorticoid receptor", TOXICOLOGY AND APPLIED PHARMACOLOGY, ACADEMIC PRESS, AMSTERDAM, NL, vol. 401, 1 July 2020 (2020-07-01), AMSTERDAM, NL , XP086215593, ISSN: 0041-008X, DOI: 10.1016/j.taap.2020.115118
KITAMURA HIDEMITSU, OHNO YOSUKE, TOYOSHIMA YUJIRO, OHTAKE JUNYA, HOMMA SHIGENORI, KAWAMURA HIDEKI, TAKAHASHI NORIHIKO, TAKETOMI AK: "Interleukin-6/STAT3 signaling as a promising target to improve the efficacy of cancer immunotherapy", CANCER SCIENCE, JAPANESE CANCER ASSOCIATION, TOKYO, JP, vol. 108, no. 10, 1 October 2017 (2017-10-01), JP , pages 1947 - 1952, XP093063572, ISSN: 1347-9032, DOI: 10.1111/cas.13332
SATORU SHINRIKI, HIROFUMI JONO, KAZUTOSHI OTA, MITSUHARU UEDA, MAREINA KUDO, TOMOKO OTA, YUICHI OIKE, MOTOYOSHI ENDO, MUTSUKO IBUS: "Humanized Anti-Interleukin-6 Receptor Antibody Suppresses Tumor Angiogenesis and In vivo Growth of Human Oral Squamous Cell Carcinoma", CLINICAL CANCER RESEARCH, ASSOCIATION FOR CANCER RESEARCH, US, vol. 15, no. 17, 1 September 2009 (2009-09-01), US, pages 5426 - 5434, XP002628465, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-09-0287
TANAKA YASUHIRO: "Dendritic cells-based cancer vaccine — Cancer immunotherapy with tumor/dendritic cell fusions —", JOURNAL OF JAPAN SOCIETY OF IMMUNOLOGY & ALLERGOLOGY IN OTOLARYNGOLOGY (JJIAO), vol. 30, no. 1, 1 January 2012 (2012-01-01), pages 1 - 7, XP093063576
MATTHIAS PEIPER; TAKEO SATO; THOMAS STREICHERT; CLAUS FERDINAND EISENBERGER; WOLFRAM TRUDO KNOEFEL; JAKOB ROBERT IZBICKI: "Cytotoxic T lymphocyte mediated recognition of human pancreatic cancer cells", INTERNATIONAL JOURNAL OF CANCER, JOHN WILEY & SONS, INC., US, vol. 99, no. 1, 25 February 2002 (2002-02-25), US , pages 88 - 92, XP071281472, ISSN: 0020-7136, DOI: 10.1002/ijc.10280
SHIMIZU KOICHI; KOTERA YOSHIHITO; ARUGA ATSUSHI; TAKESHITA NOBUHIRO; KATAGIRI SATOSHI; ARIIZUMI SHUN-ICHI; TAKAHASHI YUTAKA; YOSHI: "Postoperative dendritic cell vaccine plus activated T-cell transfer improves the survival of patients with invasive hepatocellular carcinoma", HUMAN VACCINES & IMMUNOTHERAPEUTICS, TAYLOR & FRANCIS, US, vol. 10, no. 4, 31 March 2014 (2014-03-31), US , pages 970 - 976, XP009534152, ISSN: 2164-5515, DOI: 10.4161/hv.27678
R. ZAYNAGETDINOV, T. P. SHERRILL, L. A. GLEAVES, A. G. MCLOED, J. A. SAXON, A. C. HABERMANN, L. CONNELLY, D. DULEK, R. S. PEEBLES,: "Interleukin-5 Facilitates Lung Metastasis by Modulating the Immune Microenvironment", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 75, no. 8, 15 April 2015 (2015-04-15), US, pages 1624 - 1634, XP055560684, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-14-2379
YAO YE; YAO QING-YU; XUE JUN-SHENG; TIAN XIU-YUN; AN QI-MING; CUI LI-XUAN; XU CHANG; SU HONG; YANG LIANG; FENG YAO-YAO; HAO CHUN-Y: "Dexamethasone inhibits pancreatic tumor growth in preclinical models: Involvement of activating glucocorticoid receptor", TOXICOLOGY AND APPLIED PHARMACOLOGY, ACADEMIC PRESS, AMSTERDAM, NL, vol. 401, 1 July 2020 (2020-07-01), AMSTERDAM, NL , XP086215593, ISSN: 0041-008X, DOI: 10.1016/j.taap.2020.115118
Attorney, Agent or Firm:
HARAKENZO WORLD PATENT & TRADEMARK (JP)
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