Title:
COMPOSITION FOR TREATMENT, PREVENTION, OR AMELIORATION OF LYMPHEDEMA
Document Type and Number:
WIPO Patent Application WO/2021/210925
Kind Code:
A1
Abstract:
The present invention relates to a novel compound which exhibits the effect of treating, preventing, or ameliorating lymphedema, and a composition comprising same as an active ingredient, the composition being applied as medicines, functional foods or food supplements, or cosmetics. The active ingredient compound according to the present invention exhibits a significant improvement effect on lymphedema in various terms such as TNFα production inhibitory activity, metabolic stability, solubility, and exposure in blood.
Inventors:
KU JIN-MO (KR)
LEE SUKCHAN (KR)
KANG HEE (KR)
LEE SUKCHAN (KR)
KANG HEE (KR)
Application Number:
PCT/KR2021/004725
Publication Date:
October 21, 2021
Filing Date:
April 14, 2021
Export Citation:
Assignee:
GYEONGGIDO BUSINESS & SCIENCE ACCELERATOR (KR)
RESEARCH & BUSINESS FOUND SUNGKYUNKWAN UNIV (KR)
UNIV INDUSTRY COOPERATION GROUP KYUNG HEE UNIV (KR)
RESEARCH & BUSINESS FOUND SUNGKYUNKWAN UNIV (KR)
UNIV INDUSTRY COOPERATION GROUP KYUNG HEE UNIV (KR)
International Classes:
C07C49/223; A61K8/35; A61K8/49; A61K31/12; A61K31/353; A61P7/10; A61Q19/00; C07D311/74
Domestic Patent References:
| WO2018010170A1 | 2018-01-18 |
Foreign References:
| KR101756353B1 | 2017-07-13 | |||
| KR101533197B1 | 2015-07-02 |
Other References:
ROH KANGSAN, JUNG-HUN LEE, HEE KANG, KYE WON PARK, YOUNGJU SONG, SUKCHAN LEE, JIN-MO KU: "Synthesis and evaluation of butein derivatives for in vitro and in vivo inflammatory response suppression in lymphedema", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 197, 6 April 2020 (2020-04-06), XP055859196, DOI: 10.1016/j.ejmech.2020.112280
ZHANG YALI, XU TINGTING, WU BEIBEI, CHEN HONGJIN, PAN ZHEER, HUANG YI, MEI LIQIN, DAI YUANRONG, LIU XING, SHAN XIAOOU, LIANG GUANG: "Targeting myeloid differentiation protein 2 by the new chalcone L2H21 protects LPS-induced acute lung injury", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, UNIVERSITY PRESS CAROL DAVILA, BUCHAREST, RO, vol. 21, no. 4, 1 April 2017 (2017-04-01), RO , pages 746 - 757, XP055859200, ISSN: 1582-1838, DOI: 10.1111/jcmm.13017
ZHANG YALI, XU TINGTING, WU BEIBEI, CHEN HONGJIN, PAN ZHEER, HUANG YI, MEI LIQIN, DAI YUANRONG, LIU XING, SHAN XIAOOU, LIANG GUANG: "Targeting myeloid differentiation protein 2 by the new chalcone L2H21 protects LPS-induced acute lung injury", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, UNIVERSITY PRESS CAROL DAVILA, BUCHAREST, RO, vol. 21, no. 4, 1 April 2017 (2017-04-01), RO , pages 746 - 757, XP055859200, ISSN: 1582-1838, DOI: 10.1111/jcmm.13017
Attorney, Agent or Firm:
IPSCENT (KR)
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