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Title:
COMPOSITION FOR THE TREATMENT AND PREVENTION OF HERPES SIMPLEX LABIALIS
Document Type and Number:
WIPO Patent Application WO/2012/014238
Kind Code:
A1
Abstract:
Composition for the treatment and prevention of herpes simplex labialis comprising, in combination, the following substances: Mimosa tenuiflora bark extract, Aqua, sodium carboxymethyl betaglucan, Echinacea angustifolia root extract and Glycyrrhetinic acid.

Inventors:
PASQUALI COSTANTINO (IT)
Application Number:
PCT/IT2011/000179
Publication Date:
February 02, 2012
Filing Date:
May 27, 2011
Export Citation:
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Assignee:
PASQUALI S R L (IT)
PASQUALI COSTANTINO (IT)
International Classes:
A61K31/192; A61K9/00; A61K9/06; A61K9/70; A61K31/716; A61K36/28; A61K36/48; A61K45/06; A61K47/36; A61P31/22
Domestic Patent References:
WO2010045969A12010-04-29
WO2007059441A22007-05-24
WO2008134712A22008-11-06
WO2008010241A12008-01-24
Foreign References:
GB2140809A1984-12-05
Other References:
DATABASE WPI Week 199510, Derwent World Patents Index; AN 1995-070296, XP002627027
Attorney, Agent or Firm:
MINCONE, Antimo (Firenze, IT)
Download PDF:
Claims:
CLAIMS

Composition for the treatment and prevention of herpes simplex labialis characterized by the fact that comprises, in combination, the following substances: Mimosa tenuiflora bark extract, Aqua, sodium carboxymethyl betaglucan, Echinacea angustifolia root extract and Glycyrrhetinic acid.

Composition according to claim 1 characterized in that it comprises, in combination, aqua, sorbitol, xanthan gum, panthenol, Echinacea angustifolia root extract, Mimosa tenuiflora bark extract,sodium carboxymethyl betaglucan, allantoin, glycyrrhetinic acid, benzyl alcohol, dehydroacetic acid, disodium EDTA.

Composition according to claim 1 characterized in that it comprises the following amounts of the said substances: Mimosa tenuiflora bark extract 2-4%, Aqua, sodium carboxymethyl betaglucan 1-5%, Echinacea angustifolia root extract 0.25-l%and Glycyrrhetinic acid 0.1-1%.

Composition according to claim 1 characterized in that it comprises the following amounts of the said substances: Mimosa tenuiflora bark extract 2.5%, Aqua, sodium carboxymethyl betaglucan 2%, Echinacea angustifolia root extract 0.25%and Glycyrrhetinic acid 0.15%.

Composition according to claim 1 characterized in that it is in the hydrogel form.

Composition according to claim 1 characterized in that it is transparent.

Description:
TITLE

Composition for the treatment and prevention of herpes simplex labialis.

DESCRIPTION

The present invention relates to a composition for the treatment and prevention of herpes simplex labialis.

It is known that herpes simplex is a type of virus belonging to the herpesviridae family and is the cause of two forms of herpes: HSV I and HSV II. The first form, remarkably widespread, that is responsible for the appearance of characteristics fever vesicles that usually affect the facial skin (lips, nose), is also called herpes simplex labialis. Less frequently, the vesicles may appear on the nasal mucosa (in particular, outside or inside the nostrils), on the cheeks or the palate. Initially, the herpes labialis provokes a slight tingling and a feeling of warmth on a reddened point of the lip. Within a few hours, some vesicles, often painful, begin to develop in the same area of the starting point. Once the inflammatory process is ended, the vesicles caused by herpes labialis dry up and form a small yellowish crust that disappears within 7-10 days even without any treatment. The appearance of herpes labialis can coincide with a state of malaise, nervousness, fever, after the onset of menstruation, stress, intense exposure to sunlight or after eating certain foods. The infection caused by herpes labialis can easily re-occur because the virus survives within cells and is not removed even with the use of effective medicines. The treatment usually involves the use of topical medicines with a basis of antivirals (aciclovir, famciclovir and valaciclovir) which however are able to reduce the infection without eliminating it completely.

The main purpose of the present invention is to propose a composition that allows to effectively treat and prevent the onset of the herpes simplex labialis. This result is reached, in accordance with the present invention, by adopting the idea of making a composition having the characteristics specified in claim 1. Other features of the present invention are the subject of the dependent claims.

Thanks to the present invention it is possible to effectively treat and prevent the onset of herpes simplex labialis. Furthermore, a composition in accordance with the invention accelerates the healing of injuries, relieves the associated symptoms, and is easy to apply. In particular, thanks to the present invention a bio-film is formed, that prevents the vesicles of the lesion from expanding, protects the lesion from external aggressions, and avoid the pain due to dryness, air, heat, etc., and is transparent, thus providing a significant advantages in comparison to the previously mentioned active principles (acyclovir and the like) that are of a very visible white color.

These and further advantages and features of the present invention will be more and better understood by each technical of the field thanks to the following description that provides possible examples of realization of the invention, not to be meant in a restrictive sense.

A composition in accordance with the present invention is in hydrogel form and includes aqua, sorbitol, xanthan gum, panthenol, echinacea angustifolia root extract, mimosa tenuiflora bark extract, sodium carboxymethyl betaglucan, allantoin, glycyrrhetinic acid, benzyl alcohol, dehydroacetic acid, disodium EDTA.

More specifically, a composition in accordance with the present invention can be formulated as shown in the following table A.

Preferably, the amount of the mentioned substances are those indicated in table B.

The active substances act synergistically to prevent and combat labial herpes infections through four different mechanisms:

1. formation of a protective film against external aggression and against the spread of the virus to the adjacent tissues (panthenol)

2. reinforcing action of the immune system to act against external aggression (carboxymethyl-betaglucan, Echinacea angustifolia root extract)

3. action favoring the physiological scarring (as allantoin, Echinacea angustifolia root extract)

4. soothing action (allantoin, panthenol)

The composition is applied on the lips and forms a protective film. The composition can be applied several times during the day. Substances INCI NAME Function %

Dried ext. Echinacea Immunostimulant, 0,25-1 % Echinacea tit. angustifolia root anti-inflammatory

4% extract

echinacoside

Ext. glicolico Mimosa Cicatrizing, 2-4% mimosa tenuiflora bark protective,

extract soothing,

antibacterial

Carbossimetil Aqua, sodium Immunostimulant 1-5% betaglucano carboxymethyl

sol. 2% betaglucan

Allantoina Allantoin Skin softener, 0.3-0,5% soothing

Sorbitolo sol. Sorbitol, aqua Humectant, flavor, 5-20% 70% conditioning

Gomma Xanthan gum Gelling 1-3% xantana

Isocide BAS Benzyl alcohol, Preservative 0,5-2% dehydroacetic

acid

EDTA Disodium Sequestering 0,1 -0,2% disodico EDTA

Acido 18 β Glycyrrhetinic Anti-inflammatory 0,1 -1 % glicirretico acid

Pantenolo Panthenol Moisturizing, film 0,5-3% forming, soothing

Acqua Aqua Solvent to 100 depurata

TABLE A Substances INCI Function % NAME

Dried ext. Echinacea Immunostimulant, 0,25 Echinacea tit. angustifolia anti-inflammatory 4% root extract

echinacoside

Est. glicolico Mimosa Cicatrizing, 2,5 mimosa tenuiflora bark protective,

extract soothing,

antibacterial

Carbossimetil Aqua, sodium Immunostimulant 2 betaglucano carboxymethyl

sol. 2% betaglucan

Allantoina Allantoin Skin softener, 0,3 soothing

Sorbitolo sol. Sorbitol, aqua Humectant, flavor, 10 70% conditioning

Gomma Xanthan gum Gelling 2,2 xantana

Isocide BAS Benzyl Preservative 1 alcohol,

dehydroacetic

acid

EDTA Disodium Sequestering 0,1 disodico EDTA

Acido 18 β Glycyrrhetinic Anti-inflammatory 0, 15 glicirretico acid

Pantenolo Panthenol Moisturizing, film 1 forming, soothing

Acqua Aqua Solvent to 100 depurata

TABLE B