Title:
COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/239862
Kind Code:
A1
Abstract:
Provided are extracellular vesicles derived from cells that show reduced graft rejection and have a physiological activity. The composition according to the present invention contains extracellular vesicles of a regenerative cell population, which is induced from mononuclear cells derived from a biological sample, or a culture thereof.
Inventors:
ASAHARA TAKAYUKI (JP)
SALYBEKOV A AMANKELDI (JP)
SALYBEKOV A AMANKELDI (JP)
Application Number:
PCT/JP2022/020222
Publication Date:
November 17, 2022
Filing Date:
May 13, 2022
Export Citation:
Assignee:
STEMMED INC (JP)
HUMAN LIFE CORD JAPAN INC (JP)
HUMAN LIFE CORD JAPAN INC (JP)
International Classes:
A61K35/15; A61K35/51; A61P9/10; A61P9/14; A61P43/00; C12N5/071
Domestic Patent References:
| WO2014051154A1 | 2014-04-03 |
Foreign References:
| CN111249293A | 2020-06-09 | |||
| US20200390822A1 | 2020-12-17 | |||
| JP2011529957A | 2011-12-15 | |||
| JP2021081426A | 2021-05-27 |
Other References:
SALYBEKOV AMANKELDI A., KAWAGUCHI AKIRA T., MASUDA HARUCHIKA, VORATEERA KOSIT, OKADA CHISA, ASAHARA TAKAYUKI: "Regeneration-associated cells improve recovery from myocardial infarction through enhanced vasculogenesis, anti-inflammation, and cardiomyogenesis", PLOS ONE, vol. 13, no. 11, 28 November 2018 (2018-11-28), pages e0203244, XP055801358, DOI: 10.1371/journal.pone.0203244
SALYBEKOV AMANKELDI A., SALYBEKOVA AINUR, SHENG YIN, SHINOZAKI YOSHIKO, YOKOYAMA KEIKO, KOBAYASHI SHUZO, ASAHARA TAKAYUKI: "Extracellular Vesicles Derived From Regeneration Associated Cells Preserve Heart Function After Ischemia-Induced Injury", FRONTIERS IN CARDIOVASCULAR MEDICINE, vol. 8, 1 January 2021 (2021-01-01), pages 754254, XP093003212, DOI: 10.3389/fcvm.2021.754254
MASUDA H. ET AL., CIRCULATION RESEARCH, vol. 109, 2011, pages 20 - 37
ASAHARA ET AL., SCIENCE, vol. 275, 1997, pages 964 - 7
AMANKELDI, PLOSONE, vol. 14, no. 3, 2019, pages e0205477
MASUDA H. ET AL., CIRCULATION RESEARCH, vol. 109, 2011, pages 20 - 37
SALYBEKOV AMANKELDI A., SALYBEKOVA AINUR, SHENG YIN, SHINOZAKI YOSHIKO, YOKOYAMA KEIKO, KOBAYASHI SHUZO, ASAHARA TAKAYUKI: "Extracellular Vesicles Derived From Regeneration Associated Cells Preserve Heart Function After Ischemia-Induced Injury", FRONTIERS IN CARDIOVASCULAR MEDICINE, vol. 8, 1 January 2021 (2021-01-01), pages 754254, XP093003212, DOI: 10.3389/fcvm.2021.754254
MASUDA H. ET AL., CIRCULATION RESEARCH, vol. 109, 2011, pages 20 - 37
ASAHARA ET AL., SCIENCE, vol. 275, 1997, pages 964 - 7
AMANKELDI, PLOSONE, vol. 14, no. 3, 2019, pages e0205477
MASUDA H. ET AL., CIRCULATION RESEARCH, vol. 109, 2011, pages 20 - 37
Attorney, Agent or Firm:
TSUJIMARU Koichiro et al. (JP)
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