Title:
COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2020/190217
Kind Code:
A3
Abstract:
We describe an antibody or antigen-binding fragment thereof comprising a heavy chain variable region (VH) sequence and a light chain variable region (VL) sequence of a clone selected from: 5C4, 4H1, 1D2, 1C4, 2B5, 1F1, 1H1, 4A5, 1D8, 1D3, 2F1, 3C6, 3D12, 3A9, 1F4, 1H10, 3C12, 4G11, 4A12, 1A12, 3G12, 4F9, 4G4 and 1E1 which is capable of specifically binding to glypican-3 (GPC-3) (GenBank Accession Number: NP_004475.1), or a sequence having at least 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% sequence identity thereto.
Inventors:
WANG CHENG-I (SG)
WANG BEI (SG)
NGOH ZI XIAN EVE (SG)
LEE WEN-HSIN (SG)
HUANG CHING-WEN (SG)
YEAP YEE CHIN (SG)
WANG BEI (SG)
NGOH ZI XIAN EVE (SG)
LEE WEN-HSIN (SG)
HUANG CHING-WEN (SG)
YEAP YEE CHIN (SG)
Application Number:
PCT/SG2020/050152
Publication Date:
October 22, 2020
Filing Date:
March 22, 2020
Export Citation:
Assignee:
AGENCY SCIENCE TECH & RES (SG)
International Classes:
C07K16/28; A61K35/17; A61K39/395; A61P35/00; C07K14/705; G01N33/577
Domestic Patent References:
| WO2015179658A2 | 2015-11-26 |
Foreign References:
| US20140186892A1 | 2014-07-03 | |||
| US20160215261A1 | 2016-07-28 | |||
| US7919086B2 | 2011-04-05 |
Other References:
FENG M. ET AL.: "Glypican-3 antibodies: a new therapeutic target for liver cancer", FEBS LETT., vol. 588, no. 2, 15 October 2013 (2013-10-15), pages 377 - 382, XP028669969, DOI: 10.1016/j.febslet.2013.10.002
FENG M. ET AL.: "Therapeutically targeting glypican-3 via a conformation- specific single-domain antibody in hepatocellular carcinoma", PROC NATL ACAD SCI USA, vol. 110, no. 12, 5 March 2013 (2013-03-05), pages E1083 - E1091, XP055083878, DOI: 10.1073/pnas.1217868110
YI-FAN ZHANG; MITCHELL HO: "Humanization of high-affinity antibodies targeting glypican-3 in hepatocellular carcinoma", SCI REP., 26 September 2016 (2016-09-26), pages 33878, XP055544227
MICHAEL V ORTIZ, STEPHEN S ROBERTS, JULIA GLADE BENDER, NEERAV SHUKLA, LEONARD H WEXLER: "Immunotherapeutic Targeting of GPC3 in Pediatric Solid Embryonal Tumors", FRONT ONCOL., vol. 9, 108, 26 February 2019 (2019-02-26), pages 1 - 8, XP055749000
YANLAN WANG, JIAYU LIU, HAITAO PAN, JIEYU XING, XIAOQIONG WU, QING LI, ZHONG WANG: "A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity", J VIS EXP., vol. 12, no. 137, 12 July 2018 (2018-07-12), pages e57588-1 - e57588-8, XP009531490, ISSN: 1940-087X, DOI: 10.3791/57588
FENG M. ET AL.: "Therapeutically targeting glypican-3 via a conformation- specific single-domain antibody in hepatocellular carcinoma", PROC NATL ACAD SCI USA, vol. 110, no. 12, 5 March 2013 (2013-03-05), pages E1083 - E1091, XP055083878, DOI: 10.1073/pnas.1217868110
YI-FAN ZHANG; MITCHELL HO: "Humanization of high-affinity antibodies targeting glypican-3 in hepatocellular carcinoma", SCI REP., 26 September 2016 (2016-09-26), pages 33878, XP055544227
MICHAEL V ORTIZ, STEPHEN S ROBERTS, JULIA GLADE BENDER, NEERAV SHUKLA, LEONARD H WEXLER: "Immunotherapeutic Targeting of GPC3 in Pediatric Solid Embryonal Tumors", FRONT ONCOL., vol. 9, 108, 26 February 2019 (2019-02-26), pages 1 - 8, XP055749000
YANLAN WANG, JIAYU LIU, HAITAO PAN, JIEYU XING, XIAOQIONG WU, QING LI, ZHONG WANG: "A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity", J VIS EXP., vol. 12, no. 137, 12 July 2018 (2018-07-12), pages e57588-1 - e57588-8, XP009531490, ISSN: 1940-087X, DOI: 10.3791/57588
Attorney, Agent or Firm:
KHOO, Chong-Yee (SG)
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