Title:
COMPOSITIONS OF CARBOHYDRATE VACCINE FOR INDUCING IMMUNE RESPONSE IN CANCER TREATMENT
Document Type and Number:
WIPO Patent Application WO/2015/159118
Kind Code:
A3
Abstract:
The invention encompasses therapeutic compositions including Globo H-KLH conjugates and/or therapeutic antibodies as well as methods of making and using the same to treat proliferative diseases such as cancer. The therapeutic conjugates include an antigen linked to a carrier. In particular the therapeutic conjugates include a Globo H moiety and a KLH moiety and/or a derivatized KLH moiety subunit optionally linked via a linker. The therapeutic compositions are in part envisaged to act as cancer vaccines for boosting the body's natural ability to protect itself, through the immune system from dangers posed by damaged or abnormal cells such as cancer cells. An effective immune response is one that reduces the severity of disease, including but not limited to, prevention of disease, delay in onset of disease, decreased severity of symptoms, decreased morbidity and delayed mortality.
Inventors:
YU CHENG-DER TONY (TW)
WANG CHENG-CHI IRENE (TW)
LEE WEI-HAN (TW)
LIN YU-CHEN (TW)
LIN YU-HSIN TOM (TW)
CHEN I-JU (TW)
WANG CHENG-CHI IRENE (TW)
LEE WEI-HAN (TW)
LIN YU-CHEN (TW)
LIN YU-HSIN TOM (TW)
CHEN I-JU (TW)
Application Number:
PCT/IB2014/002744
Publication Date:
March 17, 2016
Filing Date:
September 15, 2014
Export Citation:
Assignee:
OBI PHARMA INC (US)
International Classes:
A61K47/48; C07K7/06
Foreign References:
| US20130095173A1 | 2013-04-18 | |||
| US20100166790A1 | 2010-07-01 | |||
| US20100286035A1 | 2010-11-11 | |||
| US20120321583A1 | 2012-12-20 |
Other References:
BERGMAN, J ET AL.: "Efficient synthesis of 2-chloro-, 2-bromo-, and 2-iodoindole", J. ORG. CHEM., vol. 57, no. 8, 1992, pages 2495 - 2497, XP055326691, Retrieved from the Internet [retrieved on 20151118]
SPEED, MA ET AL.: "Multimeric intermediates in the pathway to the aggregated inclusion body state for P22 tailspike polypeptide chains.", PROTEIN SCIENCE, vol. 4, 1995, pages 900 - 908, XP055326889, Retrieved from the Internet [retrieved on 20151118]
WAKIMOTO, H ET AL.: "Intensified Antitumor Immunity by a Cancer Vaccine That Produces Granulocyte-Macrophage Colony-stimulating Factor plus Interleukin 4.", CANCER RESEARCH, vol. 56, 15 April 1996 (1996-04-15), pages 1828 - 1833, XP002047494, Retrieved from the Internet [retrieved on 20151118]
HIRANO, F ET AL.: "Blockade of B7-H1 and PD-1 by Monoclonal Antibodies Potentiates Cancer Therapeutic Immunity.", CANCER RES., vol. 65, no. 3, 1 February 2005 (2005-02-01), pages 1089 - 1096, XP002419626, Retrieved from the Internet [retrieved on 20151118]
SPEED, MA ET AL.: "Multimeric intermediates in the pathway to the aggregated inclusion body state for P22 tailspike polypeptide chains.", PROTEIN SCIENCE, vol. 4, 1995, pages 900 - 908, XP055326889, Retrieved from the Internet
WAKIMOTO, H ET AL.: "Intensified Antitumor Immunity by a Cancer Vaccine That Produces Granulocyte-Macrophage Colony-stimulating Factor plus Interleukin 4.", CANCER RESEARCH, vol. 56, 15 April 1996 (1996-04-15), pages 1828 - 1833, XP002047494, Retrieved from the Internet
HIRANO, F ET AL.: "Blockade of B7-H1 and PD-1 by Monoclonal Antibodies Potentiates Cancer Therapeutic Immunity.", CANCER RES., vol. 65, no. 3, 1 February 2005 (2005-02-01), pages 1089 - 1096, XP002419626, Retrieved from the Internet
Attorney, Agent or Firm:
FANELLI, Dean, L. (1300 I Street N.W., Suite 850 Wes, Washington DC, US)
Download PDF:
Previous Patent: FILLING HEAD INJECTOR FOR AEROSOL CAN WITH PROTECTIVE COVER
Next Patent: SAFETY CLOSURES AND PUMPING SYSTEMS
Next Patent: SAFETY CLOSURES AND PUMPING SYSTEMS