COMPOSITIONS OF A CHROMENE OR PHENYL ACETIC ACID CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND AN ACE INHIBITOR FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DAMAGE

Title:

COMPOSITIONS OF A CHROMENE OR PHENYL ACETIC ACID CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND AN ACE INHIBITOR FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DAMAGE

Document Type and Number:

WIPO Patent Application WO2005016249

Kind Code:

A3

Abstract:

The present invention provides compositions and methods for the treatment of central nervous system damage in a subject. More particularly, the invention provides a combination therapy for the treatment of a central nervous system ischemic condition or a central nervous system traumatic injury comprising the administration to a subject of an ACE inhibitor in combination with a chromene or phenyl acetic acid cyclooxygenase-2 selective inhibitor.

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Inventors:

STEPHENSON DIANE T (US)

Application Number:

PCT/US2004/021744

Publication Date:

November 24, 2005

Filing Date:

July 08, 2004

Export Citation:

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Assignee:

PHARMACIA CORP (US)
STEPHENSON DIANE T (US)

International Classes:

A61K31/16; A61K31/366; A61K31/415; A61K31/425; A61K31/50; A61K31/54; A61K; (IPC1-7): A61K31/54; A61K31/50; A61K31/425; A61K31/16

Foreign References:

US20020142045A1

2002-10-03

Other References:

DATABASE MEDLINE [online] TEO K.K. ET AL: "Effects of Long-Term Treatment with Angiotensin-Coverting-Enzyme Inhibitors in the Presence or Absence of Aspirin: A Systemic Review", XP002990576, Database accession no. NLM12383982

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