Title:
COMPOSITIONS COMPRISING CROSS-LINKED HYALURONIC ACID AND CYCLODEXTRIN
Document Type and Number:
WIPO Patent Application WO/2014/198683
Kind Code:
A3
Abstract:
The present invention relates to a hyaluronic acid composition comprising a hyaluronic acid and one or more cyclodextrin molecules covalently bound to said hyaluronic acid via a bi- or polyfunctional crosslinking agent, wherein the covalent bonds between said hyaluronic acid and said crosslinking agent and between said crosslinking agent and said cyclodextrin molecules are ether bonds. The present invention relates to medical and cosmetic (non-medical) uses of such compositions further comprising a pharmaceutical or medical agent and to a method of preparing a slow release formulation.
Inventors:
BOITEAU JEAN-GUY (FR)
Application Number:
PCT/EP2014/061942
Publication Date:
February 19, 2015
Filing Date:
June 09, 2014
Export Citation:
Assignee:
GALDERMA SA (CH)
International Classes:
A61K31/724; A61K8/73; A61K31/07; A61K31/728; A61Q19/00; C08B37/00
Domestic Patent References:
| WO2014055532A2 | 2014-04-10 | |||
| WO2001066601A1 | 2001-09-13 |
Foreign References:
| US20070077292A1 | 2007-04-05 | |||
| US20100028437A1 | 2010-02-04 |
Other References:
DATABASE HCAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; P MARIOTTI ET AL.: "Polysaccharide conjugates with cyclic oligosaccharides (cyclodextrins), processes for their preparation, and their uses and compositions for use in medicine and chromatography", XP002728671, Database accession no. 2007:418406
CHARLOT AURELIA ET AL: "Controlled synthesis and inclusion ability of a hyaluronic acid derivative bearing beta-cyclodextrin molecules", BIOMACROMOLECULES, vol. 7, no. 3, March 2006 (2006-03-01), pages 907 - 913, XP002728110, ISSN: 1525-7797
ZAWKO SCOTT A ET AL: "Drug-binding hydrogels of hyaluronic acid functionalized with beta-cyclodextrin.", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART A 15 DEC 2008, vol. 87, no. 4, 15 December 2008 (2008-12-15), pages 1044 - 1052, XP002728107, ISSN: 1552-4965
VAN DE MANAKKER F ET AL: "Cyclodextrin-based polymeric materials: Synthesis, properties, and pharmaceutical/biomedical applications", BIOMACROMOLECULES 20091214 AMERICAN CHEMICAL SOCIETY USA, vol. 10, no. 12, 14 December 2009 (2009-12-14), pages 3157 - 3175, XP002728108, ISSN: 1525-7797
RODRIGUEZ-TENREIRO CARMEN ET AL: "New cyclodextrin hydrogels cross-linked with diglycidylethers with a high drug loading and controlled release ability", PHARMACEUTICAL RESEARCH (DORDRECHT), vol. 23, no. 1, January 2006 (2006-01-01), pages 121 - 130, XP002728109, ISSN: 0724-8741
CHARLOT AURELIA ET AL: "Controlled synthesis and inclusion ability of a hyaluronic acid derivative bearing beta-cyclodextrin molecules", BIOMACROMOLECULES, vol. 7, no. 3, March 2006 (2006-03-01), pages 907 - 913, XP002728110, ISSN: 1525-7797
ZAWKO SCOTT A ET AL: "Drug-binding hydrogels of hyaluronic acid functionalized with beta-cyclodextrin.", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART A 15 DEC 2008, vol. 87, no. 4, 15 December 2008 (2008-12-15), pages 1044 - 1052, XP002728107, ISSN: 1552-4965
VAN DE MANAKKER F ET AL: "Cyclodextrin-based polymeric materials: Synthesis, properties, and pharmaceutical/biomedical applications", BIOMACROMOLECULES 20091214 AMERICAN CHEMICAL SOCIETY USA, vol. 10, no. 12, 14 December 2009 (2009-12-14), pages 3157 - 3175, XP002728108, ISSN: 1525-7797
RODRIGUEZ-TENREIRO CARMEN ET AL: "New cyclodextrin hydrogels cross-linked with diglycidylethers with a high drug loading and controlled release ability", PHARMACEUTICAL RESEARCH (DORDRECHT), vol. 23, no. 1, January 2006 (2006-01-01), pages 121 - 130, XP002728109, ISSN: 0724-8741
Attorney, Agent or Firm:
AWAPATENT AB (RikardBox 45086, S- Stockholm, SE)
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