COMPOSITIONS COMPRISING MENISCAL TISSUES AND USES THEREOF

WIPO Patent Application WO/2016/154452

A3

Disclosed are compositions comprising a meniscal tissue. For example, disclosed are compositions comprising a meniscal tissue, wherein the meniscal tissue comprises one or more engineered channels. Disclosed are compositions comprising a meniscal tissue comprising viable cells native to the meniscal tissue and devitalized blood vessels. Disclosed are compositions comprising a previously cryopreserved meniscal tissue, wherein after cryopreservation and subsequent thawing the meniscal tissue comprises a) cells native to the meniscal tissue and greater than 30% of the cells are viable, b) extracellular matrix that is native to the meniscal tissue, c) one or more growth factors that are native to the meniscal tissue, and d) depleted amounts of one or more types of functional immunogenic cells. Also disclosed are methods of producing and using these compositions comprising meniscal tissue.

DANILKOVITCH ALLA (US)
KUANG JINQIANG (US)
SINCLAIR STEVEN MICHAEL (US)

PCT/US2016/024042

November 03, 2016

March 24, 2016

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OSIRIS THERAPEUTICS INC (US)

A61F2/38; A61K38/18; A61L27/38; A61L27/54

US20060280768A1	2006-12-14
US5681353A	1997-10-28

HWANG, R ET AL.: "Meniscus Regeneration Through a 3D-Printed Mesenchymal Stem Cell Graft.", 1 April 2013 (2013-04-01), pages 4, Retrieved from the Internet [retrieved on 20160531]
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MARTY, Scott D. et al. (999 Peachtree StreetAtlanta, Georgia, US)

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