Title:
COMPOSITIONS COMPRISING PROGESTERONE OR PROGESTERONE ANALOGS FOR THE TREATMENT OF INFLAMMATORY CONDITIONS
Document Type and Number:
WIPO Patent Application WO2001022959
Kind Code:
A3
Abstract:
The present invention provides methods for treating inflammatory conditions, including but not limited to, inflammatory bowel disease (ulcerative colitis, Crohn's disease, and proctitis), other noninfectious, inflammatory conditions of the GI tract (microscopic colitis, allergic eosinophilic gastroenteritis, food allergies, pill induced esophagitis, celiac disease, recurrent polyps, and hemorrhoids), and psoriasis, using progesterone or progesterone analogs such as medroxyprogesterone acetate.
More Like This:
Inventors:
SCHREIBER ALAN D (US)
Application Number:
PCT/US2000/026501
Publication Date:
October 04, 2001
Filing Date:
September 27, 2000
Export Citation:
Assignee:
UNIV PENNSYLVANIA (US)
SCHREIBER ALAN D (US)
SCHREIBER ALAN D (US)
International Classes:
A61K31/57; A61P1/00; A61P9/14; A61P17/06; A61P29/00; A61P37/08; C07J5/00; (IPC1-7): A61K31/57; A61P1/00; A61P1/04; A61P17/06
Foreign References:
| US4439432A | 1984-03-27 | |||
| GB994547A | 1965-06-10 | |||
| DE2240187A1 | 1974-02-21 | |||
| US5612051A | 1997-03-18 |
Other References:
NAKAGAWA H ET AL: "ANTI INFLAMMATORY ACTION OF PROGESTERONE AND ITS POSSIBLE MODE OF ACTION IN RATS", BIOCHEMICAL PHARMACOLOGY, vol. 30, no. 6, 1981, pages 639 - 644, XP000992862, ISSN: 0006-2952
HANEY A F ET AL: "REDUCTION OF THE INTRAPERITONEAL INFLAMMATION ASSOCIATED WITH ENDOMETRIOSIS BY TREATMENT WITH MEDROXYPROGESTERONE ACETATE", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 159, no. 2, 1988, pages 450 - 454, XP000992737, ISSN: 0002-9378
REYNOLDS P D ET AL: "PHARMACOTHERAPY OF INFLAMMATORY BOWEL DISEASE", DIGESTIVE DISEASES AND SCIENCES,US,PLENUM PUBLISHING CO, vol. 11, no. 6, 1 November 1993 (1993-11-01), pages 334 - 342, XP000612355, ISSN: 0163-2116
MURCH S H ET AL: "MEDICAL MANAGEMENT OF CHRONIC INFLAMMATORY BOWEL DISEASE", BAILLIERES CLINICAL GASTROENTEROLOGY,GB,BAILLIERES TINDALL, LONDON, vol. 8, no. 1, March 1994 (1994-03-01), pages 133 - 148, XP000901064, ISSN: 0950-3528
CULLINS VANESSA E: "Noncontraceptive benefits and therapeutic uses of depot medroxyprogesterone acetate.", JOURNAL OF REPRODUCTIVE MEDICINE, vol. 41, no. 5 SUPPL., 1996, pages 428 - 433, XP000992806, ISSN: 0024-7758
ELIAKIM RAMI ET AL: "Estrogen, progesterone and the gastrointestinal tract.", JOURNAL OF REPRODUCTIVE MEDICINE, vol. 45, no. 10, October 2000 (2000-10-01), pages 781 - 788, XP000992768, ISSN: 0024-7758
HANEY A F ET AL: "REDUCTION OF THE INTRAPERITONEAL INFLAMMATION ASSOCIATED WITH ENDOMETRIOSIS BY TREATMENT WITH MEDROXYPROGESTERONE ACETATE", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 159, no. 2, 1988, pages 450 - 454, XP000992737, ISSN: 0002-9378
REYNOLDS P D ET AL: "PHARMACOTHERAPY OF INFLAMMATORY BOWEL DISEASE", DIGESTIVE DISEASES AND SCIENCES,US,PLENUM PUBLISHING CO, vol. 11, no. 6, 1 November 1993 (1993-11-01), pages 334 - 342, XP000612355, ISSN: 0163-2116
MURCH S H ET AL: "MEDICAL MANAGEMENT OF CHRONIC INFLAMMATORY BOWEL DISEASE", BAILLIERES CLINICAL GASTROENTEROLOGY,GB,BAILLIERES TINDALL, LONDON, vol. 8, no. 1, March 1994 (1994-03-01), pages 133 - 148, XP000901064, ISSN: 0950-3528
CULLINS VANESSA E: "Noncontraceptive benefits and therapeutic uses of depot medroxyprogesterone acetate.", JOURNAL OF REPRODUCTIVE MEDICINE, vol. 41, no. 5 SUPPL., 1996, pages 428 - 433, XP000992806, ISSN: 0024-7758
ELIAKIM RAMI ET AL: "Estrogen, progesterone and the gastrointestinal tract.", JOURNAL OF REPRODUCTIVE MEDICINE, vol. 45, no. 10, October 2000 (2000-10-01), pages 781 - 788, XP000992768, ISSN: 0024-7758
Download PDF: