Title:
COMPOSITIONS CONTAINING INCLUSION COMPLEXES
Document Type and Number:
WIPO Patent Application WO2002049676
Kind Code:
A3
Abstract:
The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic.
Inventors:
HWANG PUN SUZIE
GONZALEZ HECTOR
DAVIS MARK E
BELLOCQ NATHALIE
CHENG JIANJUN
GONZALEZ HECTOR
DAVIS MARK E
BELLOCQ NATHALIE
CHENG JIANJUN
Application Number:
PCT/US2001/048620
Publication Date:
December 27, 2002
Filing Date:
December 19, 2001
Export Citation:
Assignee:
CALIFORNIA INST OF TECHN (US)
INSERT THERAPEUTICS INC (US)
INSERT THERAPEUTICS INC (US)
International Classes:
A61K9/14; A61K38/00; A61K45/00; A61K47/48; A61K48/00; A61K47/34; (IPC1-7): A61K47/48; A61K47/40; A61K31/7105; A61K31/712; A61K31/13; A61K48/00
Domestic Patent References:
| WO2000033885A1 | 2000-06-15 | |||
| WO2000040962A1 | 2000-07-13 | |||
| WO2000001734A1 | 2000-01-13 |
Foreign References:
| US5691316A | 1997-11-25 | |||
| GB1390479A | 1975-04-16 | |||
| US5880154A | 1999-03-09 |
Other References:
GONZALEZ, H. ET AL.: "New class of polymers for the delivery of macromolecular therapeutics", BIOCONJUGATE CHEM, vol. 10, 1999, pages 1068 - 1074, XP002207019
OOYA, T. ET AL.: "Synthesis and characterization of an oligopeptide-terminated polyrotaxane as a drug carrier", POLYMERS FOR ADVANCED TECHNOLOGIES, vol. 11, 2000, pages 642 - 651, XP001087856
"The Merck Index 11th edition", 1989, MERCK RESEARCH LABORATORIES, WHITEHOUSE STATION NJ, XP002207313
"The Merck Index 11th edition", 1989, MERCK RESEARCH LABORATORIES, WHITEHOUSE STATION NJ, XP002207314
HWANG PUN, S. AND DAVIS, M.E.: "Development of a nonviral gene delivery vehicle for systemic application", BIOCONJUGATE CHEM, vol. 13, 2002, pages 630 - 639, XP002207020
HWANG, S.J. ET AL.: "Effects of structure of beta-cyclodextrin-containing polymers on gene delivery", BIOCONJUGATE CHEM, vol. 12, 2001, pages 280 - 290, XP002207021
OOYA, T. ET AL.: "Synthesis and characterization of an oligopeptide-terminated polyrotaxane as a drug carrier", POLYMERS FOR ADVANCED TECHNOLOGIES, vol. 11, 2000, pages 642 - 651, XP001087856
"The Merck Index 11th edition", 1989, MERCK RESEARCH LABORATORIES, WHITEHOUSE STATION NJ, XP002207313
"The Merck Index 11th edition", 1989, MERCK RESEARCH LABORATORIES, WHITEHOUSE STATION NJ, XP002207314
HWANG PUN, S. AND DAVIS, M.E.: "Development of a nonviral gene delivery vehicle for systemic application", BIOCONJUGATE CHEM, vol. 13, 2002, pages 630 - 639, XP002207020
HWANG, S.J. ET AL.: "Effects of structure of beta-cyclodextrin-containing polymers on gene delivery", BIOCONJUGATE CHEM, vol. 12, 2001, pages 280 - 290, XP002207021
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