COMPOSITIONS FOR ENCAPSULATING BIOMATERIALS AND USES RELATED THERETO

WIPO Patent Application WO/2012/129024

A3

This disclosure relates to compositions and methods for encapsulating biomaterials such as cells to prevent immune responses. In certain embodiments, the disclosure relates to capsules comprising a cell or cells gelled in alginate coated with a layer that prevents migration of immune molecules to the cell surface and an outer capsule layer comprising non-immunogenic material optionally containing immunosuppressive agents. In certain embodiments, the cells are capable of generating insulin that emanates from the capsule.

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WEBER COLLIN J (US)
SAFLEY SUSAN A (US)
GORDON KEREEN S (US)
SIMPSON NICHOLAS E (US)

PCT/US2012/029049

December 06, 2012

March 14, 2012

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UNIV EMORY (US)
WEBER COLLIN J (US)
SAFLEY SUSAN A (US)
GORDON KEREEN S (US)
SIMPSON NICHOLAS E (US)

A61K9/48; A61K9/50; A61K47/30; A61K47/48

US5578314A	1996-11-26
US20100172942A1	2010-07-08
US7824672B2	2010-11-02

P. D. VOS ET AL.: "Alginate-basedmicrocapsules for immunoisolation of pancreatic islets", BIOMATERIALS, vol. 27, 2006, pages 5603 - 5617, XP027951152
A. S. NARANG ET AL.: "Biological and biomaterial approaches for improved Islet transplantation", PHARMACOLOGICAL REVIEWS, vol. 58, no. 2, 2006, pages 194 - 243, XP008078904

MASON, James C. et al. (Office of Technology Transfer1599 Clifton Road NE, 4th Floo, Atlanta Georgia, US)

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