Title:
COMPOSITIONS FOR IMPROVING LEAN BODY MASS, BROWN ADIPOSE TISSUE AND FOR INHIBITING ADVANCED GLYCATION END PRODUCTS
Document Type and Number:
WIPO Patent Application WO/2019/077629
Kind Code:
A3
Abstract:
Synergistic herbal compositions comprising combination of extracts, fractions or phytochemicals or mixtures thereof derived from Moringa oleifera, Murraya koenigii and Curcuma longa for increasing lean body mass and brown adipose tissue; for accelerating the conversion of the white adipose tissue (WAT) to brown adipose tissue (BAT), inhibiting excessive generation of advanced glycation end (AGE) products and disease conditions associated with increased levels of advanced glycation end (AGE) products. The invention further provides a method of increasing lean body mass and brown adipose tissue; accelerating the conversion of the white adipose tissue (WAT) to brown adipose tissue (BAT), inhibiting excessive generation of advanced glycation end (AGE) products and disease conditions associated with increased levels of advanced glycation end (AGE) products in mammals.
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Inventors:
GOKARAJU GANGA RAJU (IN)
GOKARAJU RAMA RAJU (IN)
GOLAKOTI TRIMURTULU (IN)
CHIRRAVURI VENKATESWARA RAO (IN)
SOMEPALLI VENKATESWARLU (IN)
BHUPATHIRAJU KIRAN (IN)
GOKARAJU RAMA RAJU (IN)
GOLAKOTI TRIMURTULU (IN)
CHIRRAVURI VENKATESWARA RAO (IN)
SOMEPALLI VENKATESWARLU (IN)
BHUPATHIRAJU KIRAN (IN)
Application Number:
PCT/IN2018/050668
Publication Date:
June 13, 2019
Filing Date:
October 16, 2018
Export Citation:
Assignee:
LAILA NUTRACEUTICALS (IN)
International Classes:
A61K36/18; A61K36/75; A61P3/02
Foreign References:
| US8541383B2 | 2013-09-24 |
Other References:
WANG, S ET AL.: "Curcumin promotes browning of white adipose tissue in a norepinephrine-dependent way", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 466, no. 2, 2015, pages 1 - 7, XP055617076
LIN, J ET AL.: "Curcumin inhibits gene expression of receptor for advanced glycation endproducts (RAGE) in hepatic stellate cells in vitro by elevating PPARgamma activity and attenuating oxidative stress", BRITISH JOURNAL OF PHARMACOLOGY, vol. 166, 2012, pages 2212 - 2227, XP055617079
SANGKITIKOMOL, W ET AL.: "Effect of Moringa oleifera on advanced glycation end-product formation and lipid metabolism gene expression in HepG2 cells", GENETICS AND MOLECULAR RESEARCH, vol. 13, no. 1, 2014, pages 723 - 735, XP055380025
LIN, J ET AL.: "Curcumin inhibits gene expression of receptor for advanced glycation endproducts (RAGE) in hepatic stellate cells in vitro by elevating PPARgamma activity and attenuating oxidative stress", BRITISH JOURNAL OF PHARMACOLOGY, vol. 166, 2012, pages 2212 - 2227, XP055617079
SANGKITIKOMOL, W ET AL.: "Effect of Moringa oleifera on advanced glycation end-product formation and lipid metabolism gene expression in HepG2 cells", GENETICS AND MOLECULAR RESEARCH, vol. 13, no. 1, 2014, pages 723 - 735, XP055380025
Attorney, Agent or Firm:
P., Aruna Sree (IN)
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