Title:
COMPOSITIONS FOR INHIBITING DUX4 GENE EXPRESSION AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/007886
Kind Code:
A3
Abstract:
The present invention is directed to compounds, compositions, and methods useful for modulating DUX4 mRNA or protein expression using gene silencing compounds comprising two or more single stranded antisense oligonucleotides that are linked through their 5 '-ends to allow the presence of two or more accessible 3 '-ends.
Inventors:
AGRAWAL SUDHIR (US)
BHAGA LAKSHMI (US)
ZHU FU-GANG (US)
BHAGA LAKSHMI (US)
ZHU FU-GANG (US)
Application Number:
PCT/US2016/041261
Publication Date:
February 09, 2017
Filing Date:
July 07, 2016
Export Citation:
Assignee:
IDERA PHARMACEUTICALS INC (US)
International Classes:
A61K31/7105; A61K31/7088; A61K31/7125; A61P31/04; A61P31/10; A61P31/12
Domestic Patent References:
| WO2013016352A1 | 2013-01-31 | |||
| WO2011031520A1 | 2011-03-17 | |||
| WO2014043544A1 | 2014-03-20 |
Foreign References:
| US20080293655A1 | 2008-11-27 | |||
| US20130184324A1 | 2013-07-18 |
Attorney, Agent or Firm:
ZUCCHERO, Joseph, C. (US)
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