Title:
COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION AND MODULATION OF TYPE I DIABETES
Document Type and Number:
WIPO Patent Application WO2001094636
Kind Code:
A2
Abstract:
The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating type I diabetes. A variety of markers are provided, wherein changes in the levels of expression of one or more of the markers is correlated with the presence of type I diabetes.
Inventors:
BYRNE MICHAEL C
HILL ANDREW A
WILSON S BRIAN
HILL ANDREW A
WILSON S BRIAN
Application Number:
PCT/US2001/018418
Publication Date:
December 13, 2001
Filing Date:
June 05, 2001
Export Citation:
Assignee:
GENETICS INST (US)
GEN HOSPITAL CORP (US)
GEN HOSPITAL CORP (US)
International Classes:
G01N33/53; A61K38/00; A61K45/00; A61K48/00; A61P3/00; A61P3/10; A61P5/50; A61P9/00; A61P9/10; A61P13/12; A61P25/00; A61P25/02; A61P31/10; A61P43/00; C12N15/09; C12Q1/02; C12Q1/68; C12Q1/6809; C12Q1/6883; G01N33/50; G01N33/566; G01N33/68; (IPC1-7): C12Q1/68; G01N33/50; G01N33/53; G01N33/564; A61K38/17; A61K48/00; A61P31/10
Domestic Patent References:
| WO1993019174A1 | 1993-09-30 | |||
| WO1999034209A1 | 1999-07-08 | |||
| WO1997007668A1 | 1997-03-06 | |||
| WO1997007669A1 | 1997-03-06 |
Foreign References:
| US4683195A | 1987-07-28 | |||
| US4683202A | 1987-07-28 |
Other References:
EISENBARTH, N. ENGL. J. MED., vol. 214, no. 21, 1986, pages 1360 - 1368
WICKER ET AL., ANNU. REV. IMMUNOL., vol. 13, 1995, pages 179 - 200
TODDETAL, NATURE, vol. 329, 1987, pages 599 - 604
BAXTER ET AL., DIABETES, vol. 46, 1997, pages 572 - 582
LEHUEN ET AL., J. EXP. MED., vol. 188, 1998, pages 1831 - 1839
HAMMOND ET AL., J. EXP. MED., vol. 187, 1998, pages 1047 - 1056
EXLEY ET AL., J EXP. MED., vol. 186, no. 1, 1997, pages 109 - 20
WILSON ET AL., NATURE, vol. 391, no. 6663, 1998, pages 177 - 81
WILSON B ET AL.: "Extreme Th1 bias of invariant Valpha 24JalphaQT cells in type 1 diabetes", NATURE, vol. 391, 8 January 1998 (1998-01-08), pages 177 - 81
SAMBROOK, J.; FRITSH, E. F.; MANIATIS, T.: "Molecular Cloning: A Laboratory Manual.", 1989, COLD SPRING HARBOR LABORATORY PRESS
"Current Protocols in Molecular Biology", 1992, JOHN WILEY & SONS
"Current Protocols in Molecular Biology", 1989, JOHN WILEY & SONS, pages: 6.3.1 - 6.3.6
HYRUP B. ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 4, no. 1, 1996, pages 5 - 23
NEEDLEMAN; WUNSCH, J. MOL. BIOL., no. 48, 1970, pages 444 - 453
E. MEYERS; W. MILLER, CABIOS, vol. 4, 1989, pages 11 - 17
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 10
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, no. 17, 1997, pages 3389 - 3402
WILMUT, I. ET AL., NATURE, vol. 385, 1997, pages 810 - 813
LANDEGRAN ET AL., SCIENCE, vol. 241, 1988, pages 1077 - 1080
NAKAZAWA ET AL., PROC. NATL. ACAD SCI., vol. 91, 1994, pages 360 - 364
ABRAVAYA ET AL., NUCLEIC ACIDS RES, vol. 23, 1995, pages 675 - 682
EICHELBAUM, M. ET AL., CLIN. EXP. PHARMACOL. PHYSIOL., vol. 23, no. 10-11, 1996, pages 983 - 985
LINDER, M.W. ET AL., CLIN. CHEM., vol. 43, no. 2, 1997, pages 254 - 266
WICKER ET AL., ANNU. REV. IMMUNOL., vol. 13, 1995, pages 179 - 200
TODDETAL, NATURE, vol. 329, 1987, pages 599 - 604
BAXTER ET AL., DIABETES, vol. 46, 1997, pages 572 - 582
LEHUEN ET AL., J. EXP. MED., vol. 188, 1998, pages 1831 - 1839
HAMMOND ET AL., J. EXP. MED., vol. 187, 1998, pages 1047 - 1056
EXLEY ET AL., J EXP. MED., vol. 186, no. 1, 1997, pages 109 - 20
WILSON ET AL., NATURE, vol. 391, no. 6663, 1998, pages 177 - 81
WILSON B ET AL.: "Extreme Th1 bias of invariant Valpha 24JalphaQT cells in type 1 diabetes", NATURE, vol. 391, 8 January 1998 (1998-01-08), pages 177 - 81
SAMBROOK, J.; FRITSH, E. F.; MANIATIS, T.: "Molecular Cloning: A Laboratory Manual.", 1989, COLD SPRING HARBOR LABORATORY PRESS
"Current Protocols in Molecular Biology", 1992, JOHN WILEY & SONS
"Current Protocols in Molecular Biology", 1989, JOHN WILEY & SONS, pages: 6.3.1 - 6.3.6
HYRUP B. ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 4, no. 1, 1996, pages 5 - 23
NEEDLEMAN; WUNSCH, J. MOL. BIOL., no. 48, 1970, pages 444 - 453
E. MEYERS; W. MILLER, CABIOS, vol. 4, 1989, pages 11 - 17
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 10
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, no. 17, 1997, pages 3389 - 3402
WILMUT, I. ET AL., NATURE, vol. 385, 1997, pages 810 - 813
LANDEGRAN ET AL., SCIENCE, vol. 241, 1988, pages 1077 - 1080
NAKAZAWA ET AL., PROC. NATL. ACAD SCI., vol. 91, 1994, pages 360 - 364
ABRAVAYA ET AL., NUCLEIC ACIDS RES, vol. 23, 1995, pages 675 - 682
EICHELBAUM, M. ET AL., CLIN. EXP. PHARMACOL. PHYSIOL., vol. 23, no. 10-11, 1996, pages 983 - 985
LINDER, M.W. ET AL., CLIN. CHEM., vol. 43, no. 2, 1997, pages 254 - 266
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