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Title:
COMPOSITIONS AND METHOD FOR PROMOTING MUSCULOSKELETAL REPAIR
Document Type and Number:
WIPO Patent Application WO/2012/037083
Kind Code:
A3
Abstract:
A method of treating a musculoskeletal injury in a subject includes administering directly to a site of the musculoskeletal injury or to an area proximate the musculoskeletal injury an amount of SDF-1, MCP-3, or combinations thereof effective to promote repair of the musculoskeletal injury of the subject and recruit connective tissue progenitor cells to the site of the musculoskeletal injury.

Inventors:
PENN MARC S (US)
Application Number:
PCT/US2011/051340
Publication Date:
June 21, 2012
Filing Date:
September 13, 2011
Export Citation:
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Assignee:
CLEVELAND CLINIC FOUNDATION (US)
PENN MARC S (US)
International Classes:
A61K35/12; A61K35/28; A61P19/00; A61P19/10; A61P21/00
Foreign References:
US20060166361A12006-07-27
Other References:
TOSHIYUKI KITAORI ET AL.: "Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model", ARTHRITIS & RHEUMATISM, vol. 60, no. 3, 2009, pages 813 - 823, XP055004135
SOREN SCHENK ET AL.: "Monocyte chemotactic protein-3 is a myocardial mesenchymal stem cell homing factor", STEM CELLS, vol. 25, no. 1, 2007, pages 245 - 251, XP055053806
GEORGE Q. DALEY ET AL.: "Prospects for stem cell-based therapy", CELL, vol. 132, no. 4, 2008, pages 544 - 548, XP055136243
See also references of EP 2616085A4
Attorney, Agent or Firm:
SUTKUS, Richard, A. (Sundheim Covell & Tummino LLP,1300 East Ninth Street,Suite 170, Cleveland OH, US)
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