COMPOSITIONS AND METHODS FOR AMELIORATION OF HUMAN FEMALE SEXUAL DYSFUNCTION

WIPO Patent Application WO2000033825

A3

The invention provides a composition suitable for topical application comprising: an effective amount of a prostaglandin, a polymer thickener, a lipophilic component, and a buffer system. In another embodiment, the invention provides a composition suitable for topical application comprising: an effective amount of a vasoactive agent, a polymer thickener, a lipophilic component, and a buffer system. The invention also provides methods of ameliorating female sexual dysfunction. Also provided are methods of increasing female sexual arousal and methods of enhancing female sexual response.

YEAGER JAMES L
BUYUKTIMKIN NADIR
BUYUKTIMKIN SERVET

PCT/US1999/029471

November 16, 2000

December 10, 1999

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NEXMED HOLDINGS INC (US)

A61K9/00; A61K31/417; A61K31/5575; A61K47/08; A61K45/00; A61K47/10; A61K47/14; A61K47/18; A61K47/22; A61K47/30; A61K47/32; A61K47/36; A61P9/08; A61P15/12; (IPC1-7): A61K31/415; A61K31/557; A61P15/00

WO1994004120A2

1994-03-03

US5773457A	1998-06-30
US5565466A	1996-10-15

FOLDVARI M., ET AL.: "Transcutaneous delivery of prostaglandin E1: In vitro and laser doppler flowmetry study", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 87, no. 6, June 1998 (1998-06-01), pages 721 - 725, XP000917917
GOLDSTEIN I., ET AL.: "Vasculogenic female sexual dysfunction: Vaginal engorgement and clitoral erectile insufficiency syndromes", INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH, vol. 10, no. suppl. 2, 1998, pages s84 - s90, XP000891788

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