COMPOSITIONS AND METHODS FOR CANCER DIAGNOSIS AND THERAPY

WIPO Patent Application WO2004043387

A3

The miR15 and miR16 micro RNA genes are located at 13q14 within a 30 kb region of loss characteristic of cells from certain cancers, such as cells from chronic lymphocytic leukemia or prostate cancer. Chronic lymphocytic leukemia or prostate cancer can be diagnosed by detecting a reduction in miR15 or miR16 gene copy number, by determining miR15 or miR16 gene mutational status, or by detecting a reduction in the RNA transcribed from these genes. The miR15 or miR16 gene products can inhibit the neoplastic or tumorigenic growth of cancers such as chronic lymphocytic leukemia or prostate cancer cells when administered to subjects suffering from these diseases.

CROCE CARLO M (US)
CALIN GEORGE A (US)

PCT/US2003/035777

November 04, 2004

November 12, 2003

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UNIV JEFFERSON (US)
CROCE CARLO M (US)
CALIN GEORGE A (US)

A01N43/04; A61K9/127; A61K31/70; A61K48/00; C12N15/113; C12N15/63; C12Q1/68; G01N33/574; (IPC1-7): A01N43/04; A61K31/70; C12N15/00; C12N15/63

WO2003029459A2

2003-04-10

LAGOS-QUINTANA M. ET AL: "Identification of novel genes coding for small expressed RNAs", SCIENCE, vol. 294, October 2001 (2001-10-01), pages 853 - 858, XP002971837
RUVKUN G.: "Glimpses of a tiny RNA world", SCIENCE, vol. 294, October 2001 (2001-10-01), pages 797 - 799, XP002978225
CALIN G.A. ET AL: "Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia", PNAS, vol. 99, no. 24, November 2002 (2002-11-01), pages 15524 - 15529, XP002982123

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