Title:
COMPOSITIONS AND METHODS COMPRISING PROTEASE-ACTIVATED THERAPEUTIC AGENTS
Document Type and Number:
WIPO Patent Application WO/2022/236292
Kind Code:
A3
Abstract:
The disclosure relates to the engineering of collagen-binding modification of masked therapeutic agents comprising one or more tumor-associated protease cleavage sites. Upon exposure to tumor-associated proteases in the tumor microenvironment, the polypeptide is cleaved, which unmasks the therapeutic agent, reducing off-target side effects and toxicity associated with systemic administration. Accordingly, aspects of the disclosure relate to a polypeptide comprising a therapeutic agent linked to a masking agent through a linker, wherein the linker comprises one or more tumor-associated protease cleavage sites, and wherein the masking agent blocks the association of the therapeutic agent to its therapeutic target, and further wherein the polypeptide is operatively linked to a collagen binding domain or a tumor-targeting agent.
Inventors:
HUBBELL JEFFREY (US)
ISHIHARA JUN (US)
MENDOZA JUAN (US)
MANSUROV ASLAN (US)
ISHIHARA JUN (US)
MENDOZA JUAN (US)
MANSUROV ASLAN (US)
Application Number:
PCT/US2022/072121
Publication Date:
December 15, 2022
Filing Date:
May 05, 2022
Export Citation:
Assignee:
UNIV CHICAGO (US)
International Classes:
A61K38/20; A61K38/55; A61K47/62; A61K47/65; C07K14/435; C07K14/52; C07K14/54; C07K14/00; C12N15/09
Domestic Patent References:
| WO2021016640A1 | 2021-01-28 | |||
| WO2021062406A1 | 2021-04-01 |
Foreign References:
| US20110014125A1 | 2011-01-20 |
Attorney, Agent or Firm:
STELLMAN, Laurie Friesenhahn (US)
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