Title:
COMPOSITIONS AND METHODS FOR DELIVERY OF AN AGENT USING ATTENUATED SALMONELLA CONTAINING PHAGE
Document Type and Number:
WIPO Patent Application WO2001014579
Kind Code:
A3
Abstract:
The present application generally discloses delivery of an agent which can be therapeutic or prophylactic and, more particularly, the preparation and use of attenuated bacteria, such as Salmonella, containing a bacteriophage in which the genome of the bacteriophage has been modified to encode for a gene product of interest, e.g., an antigen or an anti-tumor protein. The bacteria functions as a vector for delivering the bacteriophage encoded gene product of interest to an appropriate site of action, e.g., the site of a solid tumor.
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Inventors:
BERMUDES DAVID G (US)
KING IVAN C (US)
CLAIRMONT CAROLINE A (US)
KING IVAN C (US)
CLAIRMONT CAROLINE A (US)
Application Number:
PCT/US2000/023243
Publication Date:
October 25, 2001
Filing Date:
August 24, 2000
Export Citation:
Assignee:
VION PHARMACEUTICALS INC (US)
BERMUDES DAVID G (US)
KING IVAN C (US)
CLAIRMONT CAROLINE A (US)
BERMUDES DAVID G (US)
KING IVAN C (US)
CLAIRMONT CAROLINE A (US)
International Classes:
A61K48/00; C12N1/21; (IPC1-7): A61K39/02; A61K39/112; C12P21/06; C12P21/04; C12N1/00; C12N1/20; C12N15/00; G01N33/53; C07H21/04
Domestic Patent References:
| WO1999010014A2 | 1999-03-04 |
Other References:
PAGLIA ET AL.: "Gene transfer in dendritic cells, induced by oral DNA vaccination with salmonella typhimurium in protective immunity against a murine fibrosarcoma", BLOOD, vol. 92, no. 9, 1 November 1998 (1998-11-01), pages 3172 - 3176, XP002939097
LOW ET AL.: "Lipid a mutant salmonella with suppressed virulence and TNFalpha induction retain tumor-targeting in vivo", NATURE BIOTECHNOLOGY, vol. 17, January 1999 (1999-01-01), pages 37 - 41, XP002939098
PAWELEK ET AL.: "Tumor-targeted salmonella as a novel anticancer vector", CANCER RESEARCH, vol. 57, 15 October 1997 (1997-10-15), pages 4537 - 4544, XP002939099
SALTZMAN ET AL.: "Antitumor mechanisms of attenuated salmonella typhimurium containing the gene for human interleukin-2: A novel antitumor agent", J. PEDIATRIC SURGERY, vol. 32, no. 2, February 1997 (1997-02-01), pages 301 - 306, XP002939100
LOW ET AL.: "Tumor-targeted salmonella as a novel anti-cancer vector", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, vol. 38, no. 2301, 12 April 1997 (1997-04-12) - 16 April 1997 (1997-04-16), pages 343, XP002939301
LOW ET AL.: "Lipid a mutant salmonella with suppressed virulence and TNFalpha induction retain tumor-targeting in vivo", NATURE BIOTECHNOLOGY, vol. 17, January 1999 (1999-01-01), pages 37 - 41, XP002939098
PAWELEK ET AL.: "Tumor-targeted salmonella as a novel anticancer vector", CANCER RESEARCH, vol. 57, 15 October 1997 (1997-10-15), pages 4537 - 4544, XP002939099
SALTZMAN ET AL.: "Antitumor mechanisms of attenuated salmonella typhimurium containing the gene for human interleukin-2: A novel antitumor agent", J. PEDIATRIC SURGERY, vol. 32, no. 2, February 1997 (1997-02-01), pages 301 - 306, XP002939100
LOW ET AL.: "Tumor-targeted salmonella as a novel anti-cancer vector", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, vol. 38, no. 2301, 12 April 1997 (1997-04-12) - 16 April 1997 (1997-04-16), pages 343, XP002939301
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