COMPOSITIONS AND METHODS FOR DELIVERY OF AN AGENT USING ATTENUATED SALMONELLA CONTAINING PHAGE

Title:

COMPOSITIONS AND METHODS FOR DELIVERY OF AN AGENT USING ATTENUATED SALMONELLA CONTAINING PHAGE

Document Type and Number:

WIPO Patent Application WO2001014579

Kind Code:

A9

Abstract:

The present application generally discloses delivery of an agent which can be therapeutic or prophylactic and, more particularly, the preparation and use of attenuated bacteria, such as Salmonella, containing a bacteriophage in which the genome of the bacteriophage has been modified to encode for a gene product of interest, e.g., an antigen or an anti-tumor protein. The bacteria functions as a vector for delivering the bacteriophage encoded gene product of interest to an appropriate site of action, e.g., the site of a solid tumor.

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Inventors:

BERMUDES DAVID G (US)
KING IVAN C (US)
CLAIRMONT CAROLINE A (US)

Application Number:

PCT/US2000/023243

Publication Date:

September 19, 2002

Filing Date:

August 24, 2000

Export Citation:

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Assignee:

VION PHARMACEUTICALS INC (US)
BERMUDES DAVID G (US)
KING IVAN C (US)
CLAIRMONT CAROLINE A (US)

International Classes:

A61K48/00; C12N1/21; (IPC1-7): A61K39/02; A61K39/112; C12P21/06; C12P21/04; C12N1/00; C12N1/20; C12N15/00; G01N33/53; C07H21/04

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