Title:
COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING CONDITIONS, DISORDERS, OR DISEASES INVOLVING CELL DEATH
Document Type and Number:
WIPO Patent Application WO2001076457
Kind Code:
B1
Abstract:
The present invention relates to compositions and methods for the treatment and diagnosis of conditions, disorders, or diseases involving cell death. The invention encompasses protective nucleic acids which, when introduced into a cell predisposed to undergo cell death or in the process of undergoing cell death, prevent, delay, or rescue said cell from death relative to a corresponding cell into which no exogenous nucleic acids have been introduced. The invention encompasses nucleic acids of the protective sequence, host cell expression systems of the protective sequence, hosts that have been transformed by these expression systems, including transgenic animals. The invention also encompasses protective sequence products, including proteins, polypeptides, peptides, fusion proteins, antibodies, antisense molecules or sequence, ribozyme molecules, and inhibitors or modulators directed against such protective sequences, protective sequence products, genes, gene products, and/or their regulatory elements involved in cell death.
Inventors:
THOMAS MARY BETH
PORTBURY STUART D
PURANAM KASTURI
KATZ LAWRENCE C
LO DONALD C
BARNEY SHAWN
PORTBURY STUART D
PURANAM KASTURI
KATZ LAWRENCE C
LO DONALD C
BARNEY SHAWN
Application Number:
PCT/US2001/011663
Publication Date:
July 25, 2002
Filing Date:
April 09, 2001
Export Citation:
Assignee:
COGENT NEUROSCIENCE INC (US)
International Classes:
C07K14/47; (IPC1-7): A61K39/395; A61K39/00; C07H21/04; C12Q1/68; G01N33/53
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