Title:
COMPOSITIONS AND METHODS FOR DIAGNOSTICS AND THERAPEUTICS FOR HYDROCEPHALUS
Document Type and Number:
WIPO Patent Application WO2003088919
Kind Code:
A3
Abstract:
The present disclosure relates to RFX4_v3 protein and nucleic acids encoding RFX4_v3 protein. The present disclosure provides non-human transgenic animals with altered RFX4_v3 genes, and provides assays for the detection of RFX4_v3 and RFX4_v3 polymorphisms associated with disease states. The present disclosure additionally provides methods of determining a subjects' risk of developing congenital hydrocephalus, and treating or inhibiting its development.
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Inventors:
BLACKSHEAR PERRY J (US)
ZELDIN DARRYL C (US)
GRAVES JOAN P (US)
STUMPO DEBORAH J (US)
ZELDIN DARRYL C (US)
GRAVES JOAN P (US)
STUMPO DEBORAH J (US)
Application Number:
PCT/US2003/012348
Publication Date:
October 13, 2005
Filing Date:
April 18, 2003
Export Citation:
Assignee:
US GOV HEALTH & HUMAN SERV (US)
BLACKSHEAR PERRY J (US)
ZELDIN DARRYL C (US)
GRAVES JOAN P (US)
STUMPO DEBORAH J (US)
BLACKSHEAR PERRY J (US)
ZELDIN DARRYL C (US)
GRAVES JOAN P (US)
STUMPO DEBORAH J (US)
International Classes:
C07H21/04; C07K14/47; C07K14/705; C12Q1/68; (IPC1-7): C07K1/00; A61K39/00; C07K14/00; C07K17/00
Domestic Patent References:
| WO2002086071A2 | 2002-10-31 |
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