Title:
COMPOSITIONS AND METHODS FOR EFFECTING NAD+ LEVELS USING A NICOTINAMIDE PHOSPHORIBOSYL TRANSFERASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2009/072004
Kind Code:
A3
Abstract:
The present invention relates to methods for decreasing cellular DNA repair in a target patient; decreasing cellular NAD+ biosynthesis in a target patient; increasing efficiency of radiation therapy in a target patient; modulating nicotinamide phosphoribosyl transferase activity in a patient; or sensitizing a patient to a DNA damaging therapy. The invention relates to methods for treating a patient who received a toxic dose of an nicotinamide phosphoribosyl transferase inhibitor. The invention also relates to pharmaceutical compositions comprising a physiologically acceptable carrier; an effective amount of a NMPRT inhibitor; and nicotinic acid. The invention also relates to methods for treating a patient diagnosed with or suspected to have a cancer deficient in nicotinic acid pathway.
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Inventors:
ROULSTON ANNE (CA)
BEAUPARLANT PIERRE (CA)
BEAUPARLANT PIERRE (CA)
Application Number:
PCT/IB2008/003828
Publication Date:
May 05, 2011
Filing Date:
September 25, 2008
Export Citation:
Assignee:
GEMIN X PHARMACEUTICALS CANADA INC (CA)
ROULSTON ANNE (CA)
BEAUPARLANT PIERRE (CA)
ROULSTON ANNE (CA)
BEAUPARLANT PIERRE (CA)
International Classes:
A61K31/455; A61K31/44; A61K31/4409; A61K31/4425; A61P35/00; A61P39/00
Foreign References:
| US5696140A | 1997-12-09 | |||
| US6525077B2 | 2003-02-25 | |||
| US5919816A | 1999-07-06 |
Other References:
OLESEN ET AL.: "Anticancer Agent CHS-828 Inhibits Cellular Synthesis of NAD", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 367, 15 January 2008 (2008-01-15), pages 799 - 804, XP022449876
HASMANN ET AL.: "FK866, a Highly Specific Noncompetitive Inhibitor of Nicotinamide Phosphoribosyltransferase, Represents a Novel Mechanism for Induction of Tumor Cell Apoptosis", CANCER RESEARCH, vol. 63, 1 November 2003 (2003-11-01), pages 7436 - 7442, XP002432917
HASMANN ET AL.: "FK866, a Highly Specific Noncompetitive Inhibitor of Nicotinamide Phosphoribosyltransferase, Represents a Novel Mechanism for Induction of Tumor Cell Apoptosis", CANCER RESEARCH, vol. 63, 1 November 2003 (2003-11-01), pages 7436 - 7442, XP002432917
Attorney, Agent or Firm:
WHITE, Stephanie R. (Hoskin & Harcourt LLP1900-340 Albert Stree, Ottawa Ontario K1R 7Y6, CA)
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