Title:
COMPOSITIONS AND METHODS FOR ENGINEERING CELLS
Document Type and Number:
WIPO Patent Application WO/2011/071476
Kind Code:
A3
Abstract:
The disclosure relates generally to genetic manipulation of stem and primary cells and to reprogramming of somatic cells, more specifically, human cells. In particular, compositions and methods are disclosed for the generation and maintenance of such engineered cells.
Inventors:
LAKSHMIPATHY UMA (US)
THYAGARAJAN BHASKAR (US)
CHESNUT JONATHAN (US)
ANEST VASILIKI (US)
BENNETT ROBERT (US)
LIEU PAULINE (US)
HANSON GEORGE (US)
THOMPSON DAVID (US)
CHASE LUCAS (US)
SHIPLEY GARY (US)
WILSON ELIZABETH (US)
THYAGARAJAN BHASKAR (US)
CHESNUT JONATHAN (US)
ANEST VASILIKI (US)
BENNETT ROBERT (US)
LIEU PAULINE (US)
HANSON GEORGE (US)
THOMPSON DAVID (US)
CHASE LUCAS (US)
SHIPLEY GARY (US)
WILSON ELIZABETH (US)
Application Number:
PCT/US2009/064488
Publication Date:
December 08, 2011
Filing Date:
November 13, 2009
Export Citation:
Assignee:
LIFE TECHNOLOGIES CORP (US)
LAKSHMIPATHY UMA (US)
THYAGARAJAN BHASKAR (US)
CHESNUT JONATHAN (US)
ANEST VASILIKI (US)
BENNETT ROBERT (US)
LIEU PAULINE (US)
HANSON GEORGE (US)
THOMPSON DAVID (US)
CHASE LUCAS (US)
SHIPLEY GARY (US)
WILSON ELIZABETH (US)
LAKSHMIPATHY UMA (US)
THYAGARAJAN BHASKAR (US)
CHESNUT JONATHAN (US)
ANEST VASILIKI (US)
BENNETT ROBERT (US)
LIEU PAULINE (US)
HANSON GEORGE (US)
THOMPSON DAVID (US)
CHASE LUCAS (US)
SHIPLEY GARY (US)
WILSON ELIZABETH (US)
International Classes:
C12N15/86
Domestic Patent References:
| WO1997047757A1 | 1997-12-18 | |||
| WO2000011155A1 | 2000-03-02 | |||
| WO2009149233A1 | 2009-12-10 |
Foreign References:
| US20040229229A1 | 2004-11-18 | |||
| EP2103685A1 | 2009-09-23 |
Other References:
YATES J L ET AL: "STABLE REPLICATION OF PLASMIDS DERIVED FROM EPSTEIN-BARR VIRUS IN VARIOUS MAMMALIAN CELLS", NATURE (LONDON), vol. 313, no. 6005, 1985, pages 812 - 815, XP002638217, ISSN: 0028-0836
MIN KYOUNG AH ET AL: "Prolonged gene expression in primary porcine pancreatic cells using an Epstein-Barr virus-based episomal vector.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 23 MAY 2003 LNKD- PUBMED:12732203, vol. 305, no. 1, 23 May 2003 (2003-05-23), pages 108 - 115, XP002638218, ISSN: 0006-291X
PAN G ET AL: "A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, US, vol. 20, no. 10, 1 August 2006 (2006-08-01), pages 1730 - 1732, XP008117420, ISSN: 0892-6638, [retrieved on 20060621], DOI: DOI:10.1096/FJ.05-5543FJE
SONE T ET AL: "Multi-gene gateway clone design for expression of multiple heterologous genes in living cells: Modular construction of multiple cDNA expression elements using recombinant cloning", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 136, no. 3-4, 10 September 2008 (2008-09-10), pages 113 - 121, XP024338583, ISSN: 0168-1656, [retrieved on 20080628], DOI: DOI:10.1016/J.JBIOTEC.2008.06.006
KOST ET AL: "Implementation of BacMam virus gene delivery technology in a drug discovery setting", DRUG DISCOVERY TODAY, ELSEVIER, RAHWAY, NJ, US, vol. 12, no. 9-10, 27 April 2007 (2007-04-27), pages 396 - 403, XP022063934, ISSN: 1359-6446, DOI: DOI:10.1016/J.DRUDIS.2007.02.017
THYAGARAJAN BHASKAR ET AL: "Creation of engineered human embryonic stem cell lines using phiC31 integrase", STEM CELLS (MIAMISBURG), vol. 26, no. 1, 26 October 2007 (2007-10-26), pages 119 - 126, XP002638220, ISSN: 1066-5099
YU JUNYING ET AL: "Induced pluripotent stem cell lines derived from human somatic cells", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 318, no. 5858, 21 December 2007 (2007-12-21), pages 1917 - 1920, XP009105055, ISSN: 1095-9203, DOI: DOI:10.1126/SCIENCE.1151526
MAHONEN ET AL: "Post-transcriptional regulatory element boosts baculovirus-mediated gene expression in vertebrate cells", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 131, no. 1, 13 July 2007 (2007-07-13), pages 1 - 8, XP022151834, ISSN: 0168-1656, DOI: DOI:10.1016/J.JBIOTEC.2007.05.022
KOST THOMAS A ET AL: "Baculovirus as versatile vectors for protein expression in insect and mammalian cells", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 23, no. 5, 1 May 2005 (2005-05-01), pages 567 - 575, XP002479902, ISSN: 1087-0156, [retrieved on 20050505], DOI: DOI:10.1038/NBT1095
THYAGARAJAN BHASKAR ET AL: "A single EBV-based vector for stable episomal maintenance and expression of GFP in human embryonic stem cells", REGENERATIVE MEDICINE, FUTURE MEDICINE LTD, GB, vol. 4, no. 2, 1 March 2009 (2009-03-01), pages 239 - 250, XP009148438, ISSN: 1746-0751
YU JUNYING ET AL: "Human induced pluripotent stem cells free of vector and transgene sequences", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 324, no. 5928, 8 May 2009 (2009-05-08), pages 797 - 801, XP002596377, ISSN: 1095-9203, [retrieved on 20090326], DOI: DOI:10.1126/SCIENCE.1172482
O'GRADY MICHAEL ET AL: "BacMam-mediated gene delivery into multipotent mesenchymal stromal cells.", METHODS IN MOLECULAR BIOLOGY (CLIFTON, N.J.) 2011 LNKD- PUBMED:21431539, vol. 698, 2011, pages 485 - 504, XP009148542, ISSN: 1940-6029
QUINTANILLA R., ET AL.: "Platform for efficient delivery of genes into embryonic and adult stem cells", 19 May 2011 (2011-05-19), XP002638221, Retrieved from the Internet [retrieved on 20110519]
MIN KYOUNG AH ET AL: "Prolonged gene expression in primary porcine pancreatic cells using an Epstein-Barr virus-based episomal vector.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 23 MAY 2003 LNKD- PUBMED:12732203, vol. 305, no. 1, 23 May 2003 (2003-05-23), pages 108 - 115, XP002638218, ISSN: 0006-291X
PAN G ET AL: "A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, US, vol. 20, no. 10, 1 August 2006 (2006-08-01), pages 1730 - 1732, XP008117420, ISSN: 0892-6638, [retrieved on 20060621], DOI: DOI:10.1096/FJ.05-5543FJE
SONE T ET AL: "Multi-gene gateway clone design for expression of multiple heterologous genes in living cells: Modular construction of multiple cDNA expression elements using recombinant cloning", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 136, no. 3-4, 10 September 2008 (2008-09-10), pages 113 - 121, XP024338583, ISSN: 0168-1656, [retrieved on 20080628], DOI: DOI:10.1016/J.JBIOTEC.2008.06.006
KOST ET AL: "Implementation of BacMam virus gene delivery technology in a drug discovery setting", DRUG DISCOVERY TODAY, ELSEVIER, RAHWAY, NJ, US, vol. 12, no. 9-10, 27 April 2007 (2007-04-27), pages 396 - 403, XP022063934, ISSN: 1359-6446, DOI: DOI:10.1016/J.DRUDIS.2007.02.017
THYAGARAJAN BHASKAR ET AL: "Creation of engineered human embryonic stem cell lines using phiC31 integrase", STEM CELLS (MIAMISBURG), vol. 26, no. 1, 26 October 2007 (2007-10-26), pages 119 - 126, XP002638220, ISSN: 1066-5099
YU JUNYING ET AL: "Induced pluripotent stem cell lines derived from human somatic cells", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 318, no. 5858, 21 December 2007 (2007-12-21), pages 1917 - 1920, XP009105055, ISSN: 1095-9203, DOI: DOI:10.1126/SCIENCE.1151526
MAHONEN ET AL: "Post-transcriptional regulatory element boosts baculovirus-mediated gene expression in vertebrate cells", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 131, no. 1, 13 July 2007 (2007-07-13), pages 1 - 8, XP022151834, ISSN: 0168-1656, DOI: DOI:10.1016/J.JBIOTEC.2007.05.022
KOST THOMAS A ET AL: "Baculovirus as versatile vectors for protein expression in insect and mammalian cells", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 23, no. 5, 1 May 2005 (2005-05-01), pages 567 - 575, XP002479902, ISSN: 1087-0156, [retrieved on 20050505], DOI: DOI:10.1038/NBT1095
THYAGARAJAN BHASKAR ET AL: "A single EBV-based vector for stable episomal maintenance and expression of GFP in human embryonic stem cells", REGENERATIVE MEDICINE, FUTURE MEDICINE LTD, GB, vol. 4, no. 2, 1 March 2009 (2009-03-01), pages 239 - 250, XP009148438, ISSN: 1746-0751
YU JUNYING ET AL: "Human induced pluripotent stem cells free of vector and transgene sequences", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 324, no. 5928, 8 May 2009 (2009-05-08), pages 797 - 801, XP002596377, ISSN: 1095-9203, [retrieved on 20090326], DOI: DOI:10.1126/SCIENCE.1172482
O'GRADY MICHAEL ET AL: "BacMam-mediated gene delivery into multipotent mesenchymal stromal cells.", METHODS IN MOLECULAR BIOLOGY (CLIFTON, N.J.) 2011 LNKD- PUBMED:21431539, vol. 698, 2011, pages 485 - 504, XP009148542, ISSN: 1940-6029
QUINTANILLA R., ET AL.: "Platform for efficient delivery of genes into embryonic and adult stem cells", 19 May 2011 (2011-05-19), XP002638221, Retrieved from the Internet
Attorney, Agent or Firm:
REDDY, Daphne (P.O. Box 52050Minneapolis, MN, US)
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