Title:
COMPOSITIONS AND METHODS OF EXPANSION OF T CELL POPULATIONS
Document Type and Number:
WIPO Patent Application WO/2019/140137
Kind Code:
A1
Abstract:
The present disclosure generally relates to compositions and methods useful for an adoptive cell therapy. Some embodiments of the disclosure relates to methods for producing a population of lymphocytes enriched in T stem cell memory cells (TSCM cells). Further provided are compositions containing a substantially pure population of TSCM cells that are therapeutically effective in treating various cancers, and kits containing such compositions. Methods for treating a subject having or suspected of having a cancer using the compositions and kits as disclosed herein are also provided.
Inventors:
GOOD ZINAIDA (US)
NOLAN GARRY P (US)
BENDALL SEAN C (US)
WEBER EVAN (US)
MACKALL CRYSTAL (US)
NOLAN GARRY P (US)
BENDALL SEAN C (US)
WEBER EVAN (US)
MACKALL CRYSTAL (US)
Application Number:
PCT/US2019/013115
Publication Date:
July 18, 2019
Filing Date:
January 10, 2019
Export Citation:
Assignee:
UNIV LELAND STANFORD JUNIOR (US)
International Classes:
C07K14/725; C12N5/0783
Domestic Patent References:
| WO2019014684A1 | 2019-01-17 | |||
| WO2014039044A1 | 2014-03-13 | |||
| WO2017189965A1 | 2017-11-02 |
Other References:
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MEIXIAO LONG ET AL: "Ibrutinib treatment improves T cell number and function in CLL patients", JOURNAL OF CLINICAL INVESTIGATION, vol. 127, no. 8, 1 August 2017 (2017-08-01), GB, pages 3052 - 3064, XP055572825, ISSN: 0021-9738, DOI: 10.1172/JCI89756
M. SABATINO ET AL: "Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies", BLOOD, vol. 128, no. 4, 28 July 2016 (2016-07-28), US, pages 519 - 528, XP055340306, ISSN: 0006-4971, DOI: 10.1182/blood-2015-11-683847
N. CIERI ET AL: "IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors", BLOOD, vol. 121, no. 4, 24 January 2013 (2013-01-24), US, pages 573 - 584, XP055386326, ISSN: 0006-4971, DOI: 10.1182/blood-2012-05-431718
GOOD ZINAIDA ET AL: "Proliferation tracing with single-cell mass cytometry optimizes generation of stem cell memory-like T cells", NATURE BIOTECHNOLOGY, GALE GROUP INC, NEW YORK, vol. 37, no. 3, 11 February 2019 (2019-02-11), pages 259 - 266, XP036717136, ISSN: 1087-0156, [retrieved on 20190211], DOI: 10.1038/S41587-019-0033-2
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LLOYD, THE ART, SCIENCE AND TECHNOLOGY OF PHARMACEUTICAL COMPOUNDING, 1999
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"Remington: The Science and Practice of Pharmacy", 2003, LIPPINCOTT, WILLIAMS & WILKINS
CHANG, J.T. ET AL.: "Asymmetric T lymphocyte division in the initiation of adaptive immune responses", SCIENCE, vol. 315, 2007, pages 1687 - 1691
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TUBO, N.J. ET AL.: "Most microbe-specific naive CD4(+) T cells produce memory cells during infection", SCIENCE, vol. 351, 2016, pages 511 - 514
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QUAH, B.J.; LYONS, A.B.; PARISH, C.R.: "The use of CFSE-like 788 dyes for measuring lymphocyte proliferation: experimental considerations and biological variables", MATHEMATICAL MODELLING OF NATURAL PHENOMENA, vol. 7, 2012, pages 53 - 64
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LI, Y.; KURLANDER, R.J.: "Comparison of anti-CD3 and anti-CD28-coated beads with soluble anti-CD3 for expanding human T cells: differing impact on CD8 T cell phenotype and responsiveness to restimulation", JOURNAL OF TRANSLATIONAL MEDICINE, vol. 8, 2010, pages 104, XP021078842, DOI: doi:10.1186/1479-5876-8-104
DUBOVSKY, J.A. ET AL.: "Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes", BLOOD, vol. 122, 2013, pages 2539 - 2549, XP055213911, DOI: doi:10.1182/blood-2013-06-507947
APETOH, L. ET AL.: "Consensus nomenclature for CD8+ T cell phenotypes in cancer", ONCOIMMUNOLOGY, vol. 4, 2015, pages e998538, XP055340090, DOI: doi:10.1080/2162402X.2014.998538
QUAH, B.J.; PARISH, C.R.: "The use of carboxyfluorescein diacetate succinimidyl ester (CFSE) to monitor lymphocyte proliferation", JOURNAL OF VISUALIZED EXPERIMENTS : JOVE, 2010
FLEISCHER, J. ET AL.: "Differential expression and function of CD80 (B7-1) and CD86 (B7-2) on human peripheral blood monocytes", IMMUNOLOGY, vol. 89, 1996, pages 592 - 598
JU, S.W. ET AL.: "A functional anti-human 4-1BB ligand monoclonal antibody that enhances proliferation of monocytes by reverse signaling of 4-1BBL", HYBRIDOMA AND HYBRIDOMICS, vol. 22, 2003, pages 333 - 338
ROSENBERG, S.A.; DUDLEY, M.E.: "Cancer regression in patients with metastatic melanoma after the transfer of autologous antitumor lymphocytes", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 101, no. 2, 2004, pages 14639 - 14645, XP002424289, DOI: doi:10.1073/pnas.0405730101
CHACON, J.A. ET AL.: "Co-stimulation through 4-1BB/CD137 improves the expansion and function of CD8(+) melanoma tumor-infiltrating lymphocytes for adoptive T-cell therapy", PLOS ONE, vol. 8, 2013, pages e60031
FORGET, M.A. ET AL.: "Activation and Propagation of Tumor-infiltrating Lymphocytes on Clinical-grade Designer Artificial Antigen-presenting Cells for Adoptive Immunotherapy of Melanoma", JOURNAL OF IMMUNOTHERAPY, vol. 37, 2014, pages 448 - 460, XP055441684, DOI: doi:10.1097/CJI.0000000000000056
MELLMAN, I.; COUKOS, G.; DRANOFF, G.: "Cancer immunotherapy comes of age", NATURE, vol. 480, 2011, pages 480 - 489, XP055054665, DOI: doi:10.1038/nature10673
KONO, K.: "Current status of cancer immunotherapy", JOURNAL OF STEM CELLS & REGENERATIVE MEDICINE, vol. 10, 2014, pages 8 - 13
MACKALL, C.L.; MERCHANT, M.S.; FRY, T.J.: "Immune-based therapies for childhood cancer", NATURE REVIEWS. CLINICAL ONCOLOGY, vol. 11, 2014, pages 693 - 703, XP055493874, DOI: doi:10.1038/nrclinonc.2014.177
BRENCHLEY, J.M. ET AL.: "Expansion of activated human naive T-838 cells precedes effector function", CLIN EXP IMMUNOL, vol. 130, 2002, pages 432 - 440
LIN, W.W. ET AL.: "CD8+ T Lymphocyte Self-Renewal during Effector Cell Determination", CELL REPORTS, vol. 17, 2016, pages 1773 - 1782
NISH, S.A. ET AL.: "CD4+ T cell effector commitment coupled to self-renewal by asymmetric cell divisions", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 214, 2017, pages 39 - 47
SAMUSIK, N.; GOOD, Z.; SPITZER, M.H.; DAVIS, K.L.; NOLAN, G.P.: "Automated mapping of phenotype space with single-cell data", NATURE METHODS, vol. 13, 2016, pages 493 - 496
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ZUNDER, E.R.; LUJAN, E.; GOLTSEV, Y.; WERNIG, M.; NOLAN, G.P.: "A continuous molecular roadmap to iPSC reprogramming through progression analysis of single-cell mass cytometry", CELL STEM CELL, vol. 16, 2015, pages 323 - 337
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ANGERER, P. ET AL.: "destiny: diffusion maps for large-scale single-cell data in R", BIOINFORMATICS, vol. 32, 2016, pages 1241 - 1243
NESTOROWA, S. ET AL.: "A single-cell resolution map of mouse hematopoietic stem and progenitor cell differentiation", BLOOD, vol. 128, 2016, pages e20 - 31
TIBSHIRANI, R.: "Regression shrinkage and selection via the lasso", JOURNAL OF THE ROYAL STATISTICAL SOCIETY, SERIES B, 1996, pages 267 - 288
FRIEDMAN, J.; HASTIE, T.; TIBSHIRANI, R.: "Regularization Paths for Generalized Linear Models via Coordinate Descent", J STAT SOFTW, vol. 33, 2010, pages 1 - 22, XP055480579, DOI: doi:10.18637/jss.v033.i01
XU, L.; ZHANG, Y.; LUO, G.; LI, Y.: "The roles of stem cell memory T cells in hematological malignancies", JHEMATOL ONCOL, vol. 8, 2015, pages 113, XP021229900, DOI: doi:10.1186/s13045-015-0214-5
SABATINO, M. ET AL.: "Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies", BLOOD, vol. 128, 2016, pages 519 - 528, XP055340306, DOI: doi:10.1182/blood-2015-11-683847
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MEIXIAO LONG ET AL: "Ibrutinib treatment improves T cell number and function in CLL patients", JOURNAL OF CLINICAL INVESTIGATION, vol. 127, no. 8, 1 August 2017 (2017-08-01), GB, pages 3052 - 3064, XP055572825, ISSN: 0021-9738, DOI: 10.1172/JCI89756
M. SABATINO ET AL: "Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies", BLOOD, vol. 128, no. 4, 28 July 2016 (2016-07-28), US, pages 519 - 528, XP055340306, ISSN: 0006-4971, DOI: 10.1182/blood-2015-11-683847
N. CIERI ET AL: "IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors", BLOOD, vol. 121, no. 4, 24 January 2013 (2013-01-24), US, pages 573 - 584, XP055386326, ISSN: 0006-4971, DOI: 10.1182/blood-2012-05-431718
GOOD ZINAIDA ET AL: "Proliferation tracing with single-cell mass cytometry optimizes generation of stem cell memory-like T cells", NATURE BIOTECHNOLOGY, GALE GROUP INC, NEW YORK, vol. 37, no. 3, 11 February 2019 (2019-02-11), pages 259 - 266, XP036717136, ISSN: 1087-0156, [retrieved on 20190211], DOI: 10.1038/S41587-019-0033-2
LIEBERMAN, PHARMACEUTICAL DOSAGE FORMS, vol. 1-3, 1992
LLOYD, THE ART, SCIENCE AND TECHNOLOGY OF PHARMACEUTICAL COMPOUNDING, 1999
PICKAR: "Dosage Calculations", 1999
"Remington: The Science and Practice of Pharmacy", 2003, LIPPINCOTT, WILLIAMS & WILKINS
CHANG, J.T. ET AL.: "Asymmetric T lymphocyte division in the initiation of adaptive immune responses", SCIENCE, vol. 315, 2007, pages 1687 - 1691
OLIARO, J. ET AL.: "Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms", JOURNAL OF IMMUNOLOGY, vol. 185, 2010, pages 367 - 375
GERLACH, C. ET AL.: "One naive T cell, multiple fates in CD8+ T cell differentiation", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 207, 2010, pages 1235 - 1246
GERLACH, C. ET AL.: "Heterogeneous differentiation patterns of individual CD8+ T cells", SCIENCE, vol. 340, 2013, pages 635 - 639
TUBO, N.J. ET AL.: "Most microbe-specific naive CD4(+) T cells produce memory cells during infection", SCIENCE, vol. 351, 2016, pages 511 - 514
WOODWORTH, M.B.; GIRSKIS, K.M.; WALSH, C.A.: "Building a lineage from single cells: genetic techniques for cell lineage tracking", NATURE REVIEWS. GENETICS, vol. 18, 2017, pages 230 - 244
QUAH, B.J.; LYONS, A.B.; PARISH, C.R.: "The use of CFSE-like 788 dyes for measuring lymphocyte proliferation: experimental considerations and biological variables", MATHEMATICAL MODELLING OF NATURAL PHENOMENA, vol. 7, 2012, pages 53 - 64
QUAH, B.J.; PARISH, C.R.: "New and improved methods for measuring lymphocyte proliferation in vitro and in vivo using CFSE-like fluorescent dyes", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 379, 2012, pages 1 - 14
HEINZEL, S. ET AL.: "A Myc-dependent division timer complements a cell-death timer to regulate T cell and B cell responses", NATURE IMMUNOLOGY, vol. 18, 2017, pages 96 - 103
BANDURA, D.R. ET AL.: "Mass cytometry: technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry", ANALYTICAL CHEMISTRY, vol. 81, 2009, pages 6813 - 6822, XP055188509, DOI: doi:10.1021/ac901049w
BENDALL, S.C. ET AL.: "Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum", SCIENCE, vol. 332, 2011, pages 687 - 696, XP055188486, DOI: doi:10.1126/science.1198704
LYONS, A.B.; PARISH, C.R.: "Determination of lymphocyte division by flow cytometry", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 171, 1994, pages 131 - 137, XP023986976, DOI: doi:10.1016/0022-1759(94)90236-4
ROSENBERG, S.A.; RESTIFO, N.P.: "Adoptive cell transfer as personalized immunotherapy for human cancer", SCIENCE, vol. 348, 2015, pages 62 - 68, XP055256712, DOI: doi:10.1126/science.aaa4967
GATTINONI, L.; SPEISER, D.E.; LICHTERFELD, M.; BONINI, C.: "T memory stem cells in health and disease", NATURE MEDICINE, vol. 23, 2017, pages 18 - 27
LI, Y.; KURLANDER, R.J.: "Comparison of anti-CD3 and anti-CD28-coated beads with soluble anti-CD3 for expanding human T cells: differing impact on CD8 T cell phenotype and responsiveness to restimulation", JOURNAL OF TRANSLATIONAL MEDICINE, vol. 8, 2010, pages 104, XP021078842, DOI: doi:10.1186/1479-5876-8-104
DUBOVSKY, J.A. ET AL.: "Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes", BLOOD, vol. 122, 2013, pages 2539 - 2549, XP055213911, DOI: doi:10.1182/blood-2013-06-507947
APETOH, L. ET AL.: "Consensus nomenclature for CD8+ T cell phenotypes in cancer", ONCOIMMUNOLOGY, vol. 4, 2015, pages e998538, XP055340090, DOI: doi:10.1080/2162402X.2014.998538
QUAH, B.J.; PARISH, C.R.: "The use of carboxyfluorescein diacetate succinimidyl ester (CFSE) to monitor lymphocyte proliferation", JOURNAL OF VISUALIZED EXPERIMENTS : JOVE, 2010
FLEISCHER, J. ET AL.: "Differential expression and function of CD80 (B7-1) and CD86 (B7-2) on human peripheral blood monocytes", IMMUNOLOGY, vol. 89, 1996, pages 592 - 598
JU, S.W. ET AL.: "A functional anti-human 4-1BB ligand monoclonal antibody that enhances proliferation of monocytes by reverse signaling of 4-1BBL", HYBRIDOMA AND HYBRIDOMICS, vol. 22, 2003, pages 333 - 338
ROSENBERG, S.A.; DUDLEY, M.E.: "Cancer regression in patients with metastatic melanoma after the transfer of autologous antitumor lymphocytes", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 101, no. 2, 2004, pages 14639 - 14645, XP002424289, DOI: doi:10.1073/pnas.0405730101
CHACON, J.A. ET AL.: "Co-stimulation through 4-1BB/CD137 improves the expansion and function of CD8(+) melanoma tumor-infiltrating lymphocytes for adoptive T-cell therapy", PLOS ONE, vol. 8, 2013, pages e60031
FORGET, M.A. ET AL.: "Activation and Propagation of Tumor-infiltrating Lymphocytes on Clinical-grade Designer Artificial Antigen-presenting Cells for Adoptive Immunotherapy of Melanoma", JOURNAL OF IMMUNOTHERAPY, vol. 37, 2014, pages 448 - 460, XP055441684, DOI: doi:10.1097/CJI.0000000000000056
MELLMAN, I.; COUKOS, G.; DRANOFF, G.: "Cancer immunotherapy comes of age", NATURE, vol. 480, 2011, pages 480 - 489, XP055054665, DOI: doi:10.1038/nature10673
KONO, K.: "Current status of cancer immunotherapy", JOURNAL OF STEM CELLS & REGENERATIVE MEDICINE, vol. 10, 2014, pages 8 - 13
MACKALL, C.L.; MERCHANT, M.S.; FRY, T.J.: "Immune-based therapies for childhood cancer", NATURE REVIEWS. CLINICAL ONCOLOGY, vol. 11, 2014, pages 693 - 703, XP055493874, DOI: doi:10.1038/nrclinonc.2014.177
BRENCHLEY, J.M. ET AL.: "Expansion of activated human naive T-838 cells precedes effector function", CLIN EXP IMMUNOL, vol. 130, 2002, pages 432 - 440
LIN, W.W. ET AL.: "CD8+ T Lymphocyte Self-Renewal during Effector Cell Determination", CELL REPORTS, vol. 17, 2016, pages 1773 - 1782
NISH, S.A. ET AL.: "CD4+ T cell effector commitment coupled to self-renewal by asymmetric cell divisions", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 214, 2017, pages 39 - 47
SAMUSIK, N.; GOOD, Z.; SPITZER, M.H.; DAVIS, K.L.; NOLAN, G.P.: "Automated mapping of phenotype space with single-cell data", NATURE METHODS, vol. 13, 2016, pages 493 - 496
JACOMY, M.; VENTURINI, T.; HEYMANN, S.; BASTIAN, M.: "ForceAtlas2, a continuous graph layout algorithm for handy network visualization designed for the Gephi software", PLOS ONE, vol. 9, 2014, pages e98679
ZUNDER, E.R.; LUJAN, E.; GOLTSEV, Y.; WERNIG, M.; NOLAN, G.P.: "A continuous molecular roadmap to iPSC reprogramming through progression analysis of single-cell mass cytometry", CELL STEM CELL, vol. 16, 2015, pages 323 - 337
COIFMAN, R.R. ET AL.: "Geometric diffusions as a tool for harmonic analysis and structure definition of data: diffusion maps", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, 2005, pages 7426 - 7431, XP055027881, DOI: doi:10.1073/pnas.0500334102
ANGERER, P. ET AL.: "destiny: diffusion maps for large-scale single-cell data in R", BIOINFORMATICS, vol. 32, 2016, pages 1241 - 1243
NESTOROWA, S. ET AL.: "A single-cell resolution map of mouse hematopoietic stem and progenitor cell differentiation", BLOOD, vol. 128, 2016, pages e20 - 31
TIBSHIRANI, R.: "Regression shrinkage and selection via the lasso", JOURNAL OF THE ROYAL STATISTICAL SOCIETY, SERIES B, 1996, pages 267 - 288
FRIEDMAN, J.; HASTIE, T.; TIBSHIRANI, R.: "Regularization Paths for Generalized Linear Models via Coordinate Descent", J STAT SOFTW, vol. 33, 2010, pages 1 - 22, XP055480579, DOI: doi:10.18637/jss.v033.i01
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