Title:
COMPOSITIONS AND METHODS FOR GENERATING AN IMMUNE RESPONSE UTILIZING ALPHAVIRUS-BASED VECTOR SYSTEMS
Document Type and Number:
WIPO Patent Application WO2001081609
Kind Code:
A3
Abstract:
Methods are provided for generating immune responses utilizing alphavirus-based vector systems. Specifically, compositions and methods for priming the immune system of an animal using a first immunogenic composition followed by boosting the immune system with a second immunogenic composition are disclosed.
More Like This:
Inventors:
POLO JOHN M (US)
DUBENSKY THOMAS W JR (US)
FROLOV ILYA (US)
GARDNER JASON P (US)
OTTEN GILLIS (US)
BARNETT SUSAN (US)
DRIVER DAVID A (US)
DUBENSKY THOMAS W JR (US)
FROLOV ILYA (US)
GARDNER JASON P (US)
OTTEN GILLIS (US)
BARNETT SUSAN (US)
DRIVER DAVID A (US)
Application Number:
PCT/US2001/009326
Publication Date:
February 28, 2002
Filing Date:
March 22, 2001
Export Citation:
Assignee:
CHIRON CORP (US)
POLO JOHN M (US)
DUBENSKY THOMAS W JR (US)
FROLOV ILYA (US)
GARDNER JASON P (US)
OTTEN GILLIS (US)
BARNETT SUSAN (US)
DRIVER DAVID A (US)
POLO JOHN M (US)
DUBENSKY THOMAS W JR (US)
FROLOV ILYA (US)
GARDNER JASON P (US)
OTTEN GILLIS (US)
BARNETT SUSAN (US)
DRIVER DAVID A (US)
International Classes:
C07K14/16; C12N15/86; (IPC1-7): C12N15/86; A61K39/12; A61K39/295; C07K14/18
Domestic Patent References:
| WO1998036779A2 | 1998-08-27 |
Other References:
GIRARD M ET AL: "NEW PROSPECTS FOR THE DEVELOPMENT OF A VACCINE AGAINST HUMAN IMMUNODEFICIENCY VIRUS TYPE 1. AN OVERVIEW VACCIN CONTRE LE VIRUS DE L'IMMUNODEFICIENCE HUMAINE DE TYPE 1. NOUVELLES PERSPECTIVES", COMPTES RENDUS DES SEANCES DE L'ACADEMIE DES SCIENCES. SERIE III: SCIENCES DE LA VIE, ELSEVIER, AMSTERDAM, NL, vol. 322, no. 11, November 1999 (1999-11-01), pages 959 - 966, XP001016242, ISSN: 0764-4469
PUSHKO P ET AL: "Replicon-helper systems from attenuated Venezuelan Equine Encephalitis virus: Expression of heterologous genes in vitro and immunization against heterologous pathogens in vivo", VIROLOGY,US,ACADEMIC PRESS,ORLANDO, vol. 239, no. 2, 22 December 1997 (1997-12-22), pages 389 - 401, XP002123951, ISSN: 0042-6822
PUSHKO P ET AL: "Replicon-helper systems from attenuated Venezuelan Equine Encephalitis virus: Expression of heterologous genes in vitro and immunization against heterologous pathogens in vivo", VIROLOGY,US,ACADEMIC PRESS,ORLANDO, vol. 239, no. 2, 22 December 1997 (1997-12-22), pages 389 - 401, XP002123951, ISSN: 0042-6822
Download PDF:
Previous Patent: VIRAL VECTORS FOR USE IN MONITORING HIV DRUG RESISTANCE
Next Patent: METHOD FOR PRODUCING POLYLACTIC ACID AND CORRESPONDING DEVICE
Next Patent: METHOD FOR PRODUCING POLYLACTIC ACID AND CORRESPONDING DEVICE