Title:
COMPOSITIONS AND METHODS FOR IDENTIFICATION OF ANTIGEN SPECIFIC T CELLS
Document Type and Number:
WIPO Patent Application WO/2020/167918
Kind Code:
A8
Abstract:
Disclosed herein are antigenic peptide-MHC complexes, termed comPACT polypeptides and comPACT polynucleotides, and methods of producing such complexes. Also discloses herein are methods of producing libraries of comPACT polynucleotides and polypeptides, and their exemplary use in capturing cancer neoepitope-reactive T cells with high accuracy. Dual particle detection approaches for detection of neoantigen specific T cells with improved sensitivity and specificity are provided. Signal to noise ratio analysis of isolated T cells for detection of neoantigen-specific T cells with improved T cells is also provided.
Inventors:
PENG SONGMING (US)
QUACH BOI (US)
AN DUO (US)
BAO XIAOYAN (US)
FRANZUSOFF ALEXIS (US)
SENNINO BARBARA (US)
DALMAS OLIVIER (US)
MANDL-CASHMAN STEFANIE (US)
QUACH BOI (US)
AN DUO (US)
BAO XIAOYAN (US)
FRANZUSOFF ALEXIS (US)
SENNINO BARBARA (US)
DALMAS OLIVIER (US)
MANDL-CASHMAN STEFANIE (US)
Application Number:
PCT/US2020/017887
Publication Date:
September 17, 2020
Filing Date:
February 12, 2020
Export Citation:
Assignee:
PACT PHARMA INC (US)
International Classes:
C07K14/705; C12Q1/6876; G01N33/58
Attorney, Agent or Firm:
LENDARIS, Steven, P. et al. (US)
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