Title:
COMPOSITIONS AND METHODS FOR IMMUNE TOLERANCE INDUCTION TO FACTOR VIII REPLACEMENT THERAPIES IN SUBJECTS WITH HEMOPHILIA A
Document Type and Number:
WIPO Patent Application WO/2014/145524
Kind Code:
A3
Abstract:
Tolerance inducing peptide (TIP) derived from the amino acid reference locus (AARL) within a FVIII replacement product (FVIIIrp) based on the differences between the expression product of a subject's F8 gene (sFVIII) and the FVIIIrp to provide tolerance induction before, during, and/or after a FVIII replacement therapy in a subject suffering from Hemophila A is disclosed. Methods of deriving, making, and using the TIP are also disclosed. In some embodiments, the TIP is associated with a nanoparticle, e.g., PLGA or PLGA-PEMA nanoparticle.
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Inventors:
HOWARD TOMMY E (US)
LA TERZA VINCENT (US)
LA TERZA VINCENT (US)
Application Number:
PCT/US2014/030314
Publication Date:
January 29, 2015
Filing Date:
March 17, 2014
Export Citation:
Assignee:
HAPLOMICS INC (US)
UNIV CALIFORNIA (US)
US DEPT VETERANS AFFAIRS (US)
UNIV CALIFORNIA (US)
US DEPT VETERANS AFFAIRS (US)
International Classes:
A61K39/00; A61K38/00; A61K38/04; C07K5/00; C07K7/00; C07K16/00; C07K17/00
Foreign References:
| US20040096456A1 | 2004-05-20 | |||
| US20110177107A1 | 2011-07-21 | |||
| US20050256304A1 | 2005-11-17 |
Other References:
DATABASE PROD [online] 6 March 2013 (2013-03-06), XP055277769, retrieved from NCBI Database accession no. FA8_HUMAN
See also references of EP 2968499A4
See also references of EP 2968499A4
Attorney, Agent or Firm:
FAHRNI, MengMeng, Anne (LLC4224 Wieuca Overlook, NE,Suite Nov, Atlanta GA, US)
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