Title:
COMPOSITIONS AND METHODS FOR IMPROVING HEALTH THROUGH MODULATING CALHM2
Document Type and Number:
WIPO Patent Application WO/2020/210942
Kind Code:
A1
Abstract:
Compositions and methods for improving health through modulating calcium homeostasis modulator 2 (CALHM2) are provided in the present disclosure. The methods may include administering, to a subject, a pharmaceutical composition including an effective amount of one or more agents that decrease CALHM2 function level in the at least one body part of the subject. The compositions may include one or more agents that decrease CALHM2 function level in at least one body part of a subject.
Inventors:
WANG SHIQIANG (CN)
GUO QIANJIN (CN)
ZHANG JINGRUO (CN)
GUO QIANJIN (CN)
ZHANG JINGRUO (CN)
Application Number:
PCT/CN2019/082674
Publication Date:
October 22, 2020
Filing Date:
April 15, 2019
Export Citation:
Assignee:
UNIV BEIJING (CN)
International Classes:
C12N15/11; A61K39/395; A61K48/00; A61P39/06
Domestic Patent References:
| WO2009023145A2 | 2009-02-19 |
Other References:
GÖRLACH, AGNES ET AL.: "Calcium and ROS: A mutual interplay", REDOX BIOLOGY, vol. 6, 11 August 2015 (2015-08-11), XP055746368, DOI: 20200115192530Y
MA, JUN ET AL: "Calhm2 governs astrocytic ATP releasing in the development of depression-like behaviors", MOL PSYCHIATRY, vol. 23, no. 4, 28 November 2017 (2017-11-28), XP055746372, DOI: 20200115171225X
ASHO, AGARWAL ET AL: "Oxidation-reduction potential as a new marker for oxidative stress: Correlation to male infertility", INVESTIG CLIN UROL., vol. 58, no. 6, 2 November 2017 (2017-11-02), XP055746373, DOI: 20200115171541Y
GRANGER, DN ET AL: "Reperfusion injury and reactive oxygen species: The evolution of a concept", REDOX BIOL., vol. 6, 8 October 2015 (2015-10-08), XP055746378, DOI: 20200115171757Y
KUDRYAVTSEVA AV ET AL: "Mitochondrial dysfunction and oxidative stress in aging and cancer", ONCOTARGET, vol. 7, no. 29, 5 June 2016 (2016-06-05), XP055746384, DOI: 20200115172147Y
MA, JUN ET AL: "Calhm2 governs astrocytic ATP releasing in the development of depression-like behaviors", MOL PSYCHIATRY, vol. 23, no. 4, 28 November 2017 (2017-11-28), XP055746372, DOI: 20200115171225X
ASHO, AGARWAL ET AL: "Oxidation-reduction potential as a new marker for oxidative stress: Correlation to male infertility", INVESTIG CLIN UROL., vol. 58, no. 6, 2 November 2017 (2017-11-02), XP055746373, DOI: 20200115171541Y
GRANGER, DN ET AL: "Reperfusion injury and reactive oxygen species: The evolution of a concept", REDOX BIOL., vol. 6, 8 October 2015 (2015-10-08), XP055746378, DOI: 20200115171757Y
KUDRYAVTSEVA AV ET AL: "Mitochondrial dysfunction and oxidative stress in aging and cancer", ONCOTARGET, vol. 7, no. 29, 5 June 2016 (2016-06-05), XP055746384, DOI: 20200115172147Y
Attorney, Agent or Firm:
METIS IP (CHENGDU) LLC (CN)
Download PDF: