Title:
COMPOSITIONS AND METHODS FOR INCREASING DESIRABLE MICROBIOTA
Document Type and Number:
WIPO Patent Application WO/2013/032744
Kind Code:
A3
Abstract:
A formulation to increase the ratio of gastrointestinal microbiota in phylum Bacteroidetes to microbiota of Firmicutes phylum preferably includes about 20-60 mg/kg of body weight of fermentable fiber, about 10-30 mg/kg of body weight of beta glucan and about 20-60 mg/kg of body weight of blueberry extracts or any fruit or berry ingredient preparation containing similar phenolics. This formulation is preferably used to control body weight, body composition, and blood glucose regulation, preferably in humans, and is preferably administered orally, preferably twice per day.
More Like This:
| JP3066580 | [Title of the Invention] Foods using chitosan and methods for producing the same. |
| JPS6467165 | FOOD CONTAINING EDIBLE FIBER |
| WO/1991/010440 | DIETARY SUPPLEMENT |
Inventors:
HEIMAN MARK L (US)
STULL DEAN P (US)
PENO JUSTIN W (US)
STULL DEAN P (US)
PENO JUSTIN W (US)
Application Number:
PCT/US2012/051408
Publication Date:
June 20, 2013
Filing Date:
August 17, 2012
Export Citation:
Assignee:
NUME HEALTH LLC (US)
HEIMAN MARK L (US)
STULL DEAN P (US)
PENO JUSTIN W (US)
HEIMAN MARK L (US)
STULL DEAN P (US)
PENO JUSTIN W (US)
International Classes:
A23L1/308; A61K31/733; A61K31/353; A61K31/702; A61K31/716; A61P1/00; A61P3/00
Domestic Patent References:
| WO2000064282A1 | 2000-11-02 | |||
| WO2011060307A2 | 2011-05-19 |
Foreign References:
| EP1600061A1 | 2005-11-30 | |||
| EP1214893A1 | 2002-06-19 |
Other References:
SANJAY KALRA: "Emerging role of dipeptidyl peptidase-IV (DPP-4) inhibitor vildagliptin in the management of type 2 diabetes", J. ASSOC. PHYSICIANS INDIA, vol. 59, April 2011 (2011-04-01), pages 237 - 245, XP055072381
LI, YUEL ET AL.: "Protective effect of dietary fiber on intestinal mucosa barrier in inflammatory bowel diseases rats", CHINA MEDICAL HERALD, 2010, pages 22 - 23, XP008173087, Retrieved from the Internet [retrieved on 20130125]
CAVET M. E. ET AL.: "Anti-inflammatory and anti-oxidative effects of the green tea polyphenol epigallocatechin gallate in human corneal epithelial cells", MOL. VIS., vol. 17, 18 February 2011 (2011-02-18), pages 533 - 542, XP055072383
TARINI J. ET AL.: "The fermentable fibre inulin increases postprandial serum short- chain fatty acids and reduces free-fatty acids and ghrelin in healthy subjects", APPL. PHYSIOL. NUTR. METAB., vol. 35, no. 1, February 2010 (2010-02-01), pages 9 - 16, XP008173122
VOS A.P. ET AL.: "Immune-modulatory effects and potential working mechanisms of orally applied nondigestible carbohydrates", CRIT. REV. IMMUNOL., vol. 27, no. 2, 2007, pages 97 - 140, XP009162469
JUHEL C. ET AL.: "Cholesterol-lowering effect of non-viscous soluble dietary fiber Nutriose6 in moderately hypercholesterolemic hamsters", INDIAN J. EXP. BIOL., vol. 49, no. 3, March 2011 (2011-03-01), pages 219 - 28, XP055072384
LI, YUEL ET AL.: "Protective effect of dietary fiber on intestinal mucosa barrier in inflammatory bowel diseases rats", CHINA MEDICAL HERALD, 2010, pages 22 - 23, XP008173087, Retrieved from the Internet
CAVET M. E. ET AL.: "Anti-inflammatory and anti-oxidative effects of the green tea polyphenol epigallocatechin gallate in human corneal epithelial cells", MOL. VIS., vol. 17, 18 February 2011 (2011-02-18), pages 533 - 542, XP055072383
TARINI J. ET AL.: "The fermentable fibre inulin increases postprandial serum short- chain fatty acids and reduces free-fatty acids and ghrelin in healthy subjects", APPL. PHYSIOL. NUTR. METAB., vol. 35, no. 1, February 2010 (2010-02-01), pages 9 - 16, XP008173122
VOS A.P. ET AL.: "Immune-modulatory effects and potential working mechanisms of orally applied nondigestible carbohydrates", CRIT. REV. IMMUNOL., vol. 27, no. 2, 2007, pages 97 - 140, XP009162469
JUHEL C. ET AL.: "Cholesterol-lowering effect of non-viscous soluble dietary fiber Nutriose6 in moderately hypercholesterolemic hamsters", INDIAN J. EXP. BIOL., vol. 49, no. 3, March 2011 (2011-03-01), pages 219 - 28, XP055072384
Attorney, Agent or Firm:
FITZPATRICK, Julia, M. et al. (Smith Nehrbass & North, L.L.C.,3838 N. Causeway Blvd., Suite 329, Metairie Louisiana, US)
Download PDF: