Title:
COMPOSITIONS AND METHODS FOR INCREASING ERYTHROPOIETIN (EPO) PRODUCTION
Document Type and Number:
WIPO Patent Application WO/2012/078967
Kind Code:
A3
Abstract:
The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting one or more EGLN genes, EGLN1, EGLN2 and/or EGLN3 and methods of using such dsRNA compositions to inhibit expression ofthese genes. An exemplary composition comprises at least one double-stranded ribonucleic acid (dsRNA) for inhibiting expression ofEGLNI, wherein said dsRNA comprises a sense strand and an antisense strand, wherein the sense strand comprises at least contiguous nucleotides differing by no more than 3 nucleotides from the nucleotide sequence of sequences listed in Tables 2A-F and 6A-C and the antisense strand comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from the nucleotide sequence of sequences listed in Tables 2A-F and 6A-C.
Inventors:
KAELIN JR WILLIAM G (US)
KOTELIANSKI VICTOR (US)
QUERBES WILLIAM (US)
BETTENCOURT BRIAN (US)
KOTELIANSKI VICTOR (US)
QUERBES WILLIAM (US)
BETTENCOURT BRIAN (US)
Application Number:
PCT/US2011/064121
Publication Date:
September 27, 2012
Filing Date:
December 09, 2011
Export Citation:
Assignee:
ALNYLAM PHARMACEUTICALS INC (US)
KAELIN JR WILLIAM G (US)
KOTELIANSKI VICTOR (US)
QUERBES WILLIAM (US)
BETTENCOURT BRIAN (US)
KAELIN JR WILLIAM G (US)
KOTELIANSKI VICTOR (US)
QUERBES WILLIAM (US)
BETTENCOURT BRIAN (US)
International Classes:
C12N15/113
Domestic Patent References:
| WO2009002533A1 | 2008-12-31 | |||
| WO2010084134A1 | 2010-07-29 | |||
| WO2010030396A2 | 2010-03-18 | |||
| WO2007005504A2 | 2007-01-11 |
Foreign References:
| US20090176726A1 | 2009-07-09 |
Other References:
BERRA ET AL.: "HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1a in normoxia", THE EMBO JOUMAL, vol. 22, no. 16, 15 August 2003 (2003-08-15), pages 4082 - 4090, XP002720035
WU ET AL.: "Enhancement of Angiogenesis Through Stabilization of Hypoxia-inducible Factor-1 by Silencing Prolyl Hydroxylase Domain-2 Gene", MOLECULAR THERAPY, vol. 16, no. 7, 20 May 2008 (2008-05-20), pages 1227 - 1234, XP055101077
WU ET AL.: "Enhancement of Angiogenesis Through Stabilization of Hypoxia-inducible Factor-1 by Silencing Prolyl Hydroxylase Domain-2 Gene", MOLECULAR THERAPY, vol. 16, no. 7, 20 May 2008 (2008-05-20), pages 1227 - 1234, XP055101077
Attorney, Agent or Firm:
WARD, Donna T. (P.C.292 Main Street, Suite, Groton MA, US)
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