Title:
COMPOSITIONS AND METHODS FOR INHIBITING CARP-1 BINDING TO NEMO
Document Type and Number:
WIPO Patent Application WO/2021/067572
Kind Code:
A3
Abstract:
Described herein are compositions and methods for treating cancer in a subject. The compositions include selective NF-kB inhibitor inhibitors. The methods include inhibiting the binding of CARP-1 with NEMO.
Inventors:
RISHI ARUN (US)
GAVANDE NAVNATH (US)
GAVANDE NAVNATH (US)
Application Number:
PCT/US2020/053759
Publication Date:
July 01, 2021
Filing Date:
October 01, 2020
Export Citation:
Assignee:
US GOV VETERANS AFFAIRS (US)
UNIV WAYNE STATE (US)
UNIV WAYNE STATE (US)
International Classes:
A61K31/433; C07D413/12; C07D417/12
Foreign References:
| US20180169078A1 | 2018-06-21 | |||
| US20140221412A1 | 2014-08-07 | |||
| US20090035310A1 | 2009-02-05 |
Other References:
PRALAY MAJUMDER, LIYUE ZHANG, ANIL WALI, ADHIP MAJUMDAR, ARUN RISHI: "Cell cycle and apoptosis regulatory protein (CARP)-1 is a novel regulator of TNFalpha-dependent NFkB signaling", CANCER RESEARCH, vol. 68, no. 9, 30 April 2008 (2008-04-30), pages 1 - 3, XP009529692
DATABASE Compound Pub Chem; PUBCHEM: "1-Phenyl-2-[[4-[3-(trifluoromethyl)phenyl]-1,2,4-triazol-3-yl]sulfinyl]ethanone | C17H12F3N3O2S - PubChem", XP055835003, retrieved from NCBI
DATABASE Compound Pub Chem; PUBCHEM: "1-Phenyl-2-[[4-[3-(trifluoromethyl)phenyl]-1,2,4-triazol-3-yl]sulfinyl]ethanone | C17H12F3N3O2S - PubChem", XP055835003, retrieved from NCBI
Attorney, Agent or Firm:
MARTY, Scott, D. et al. (US)
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