Title:
COMPOSITIONS AND METHODS FOR INHIBITING PLP1 EXPRESSION
Document Type and Number:
WIPO Patent Application WO/2022/031847
Kind Code:
A3
Abstract:
Oligonucleotides are provided herein that inhibit PLP1 expression. Also provided are compositions including the same and uses thereof, particularly uses relating to treating diseases, disorders and/or conditions associated with PLP1 expression.
Inventors:
BROWN BOB DALE (US)
OSBORN MAIRE (US)
CHANGELIAN ARMEN (US)
ZHANG CHUNYANG (US)
OSBORN MAIRE (US)
CHANGELIAN ARMEN (US)
ZHANG CHUNYANG (US)
Application Number:
PCT/US2021/044541
Publication Date:
April 14, 2022
Filing Date:
August 04, 2021
Export Citation:
Assignee:
DICERNA PHARMACEUTICALS INC (US)
International Classes:
A61K31/713; C12N15/113
Domestic Patent References:
| WO2009099991A2 | 2009-08-13 | |||
| WO2008020435A2 | 2008-02-21 | |||
| WO2019156115A1 | 2019-08-15 |
Foreign References:
| EP1752536A1 | 2007-02-14 |
Other References:
LI HENG ET AL: "Gene suppressing therapy for Pelizaeus-Merzbacher disease using artificial microRNA", JCI INSIGHT, vol. 4, no. 10, 16 May 2019 (2019-05-16), XP055845771, Retrieved from the Internet DOI: 10.1172/jci.insight.125052
SAADIA A. KARIM ET AL: "PLP/DM20 Expression and turnover in a transgenic mouse model of pelizaeus-merzbacher disease", GLIA, vol. 58, no. 14, 13 July 2010 (2010-07-13), US, pages 1727 - 1738, XP055751940, ISSN: 0894-1491, DOI: 10.1002/glia.21043
SAADIA A. KARIM ET AL: "PLP/DM20 Expression and turnover in a transgenic mouse model of pelizaeus-merzbacher disease", GLIA, vol. 58, no. 14, 13 July 2010 (2010-07-13), US, pages 1727 - 1738, XP055751940, ISSN: 0894-1491, DOI: 10.1002/glia.21043
Attorney, Agent or Firm:
MANDRAGOURAS, Amy et al. (US)
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