Title:
COMPOSITIONS AND METHODS FOR INHIBITION OF CATHEPSINS
Document Type and Number:
WIPO Patent Application WO/2013/142038
Kind Code:
A3
Abstract:
The disclosure is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin K or cathepsin L, will be therapeutically useful. In another implementation, the disclosure provides a method of inhibiting a neoplasm, comprising administering to a patient suffering from such neoplasm an amount of the compound effective to treat the neoplasm. In other implementations, the compounds described herein can be used to treat non-neoplastic conditions such as osteoporosis, viral infections and parasites, particularly protozoal parasites.
Inventors:
CHAPLIN DAVID J (GB)
GADDALE DEVANNA KUMAR KISHORE (GB)
PARKER ERICA (US)
PINNEY KEVIN G (US)
SONG JIANGLI (US)
TRAWICK MARY L (US)
GADDALE DEVANNA KUMAR KISHORE (GB)
PARKER ERICA (US)
PINNEY KEVIN G (US)
SONG JIANGLI (US)
TRAWICK MARY L (US)
Application Number:
PCT/US2013/029106
Publication Date:
June 18, 2015
Filing Date:
March 05, 2013
Export Citation:
Assignee:
OXIGENE INC (US)
UNIV BAYLOR (US)
UNIV BAYLOR (US)
International Classes:
A61K31/17; A01N47/28; A61K31/175
Foreign References:
| US20110305632A1 | 2011-12-15 | |||
| US20090076076A1 | 2009-03-19 |
Other References:
KISHORE KUMAR ET AL.: "Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, no. 4, 2010, pages 1415 - 1419, XP026887081
Attorney, Agent or Firm:
FLICK, Karen, E. (El Granada, CA, US)
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