Title:
COMPOSITIONS AND METHODS FOR LONG ACTING PROTEINS
Document Type and Number:
WIPO Patent Application WO/2015/198240
Kind Code:
A3
Abstract:
The present invention provides peptide tags that can be linked to a therapeutic molecule in order to decrease the clearance of the therapeutic molecule from the synovial joint, thereby increasing its intra-articular half-life.
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Inventors:
DAWSON KING JANET (CH)
GHOSH JOY (US)
NUESSLEIN-HILDESHEIM BARBARA (CH)
GHOSH JOY (US)
NUESSLEIN-HILDESHEIM BARBARA (CH)
Application Number:
PCT/IB2015/054737
Publication Date:
March 17, 2016
Filing Date:
June 24, 2015
Export Citation:
Assignee:
NOVARTIS AG (CH)
DAWSON KING JANET (CH)
GHOSH JOY (US)
NUESSLEIN-HILDESHEIM BARBARA (CH)
DAWSON KING JANET (CH)
GHOSH JOY (US)
NUESSLEIN-HILDESHEIM BARBARA (CH)
International Classes:
C07K14/47
Domestic Patent References:
| WO2013063155A2 | 2013-05-02 | |||
| WO2014099997A1 | 2014-06-26 |
Foreign References:
| US20060239965A1 | 2006-10-26 |
Other References:
D. J. MAHONEY: "Mapping the Hyaluronan-binding Site on the Link Module from Human Tumor Necrosis Factor-stimulated Gene-6 by Site-directed Mutagenesis", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 25, 15 June 2001 (2001-06-15), pages 22764 - 22771, XP055107438, ISSN: 0021-9258, DOI: 10.1074/jbc.M100666200
WISNIEWSKI H-G ET AL: "TSG-6, AN ARTHRITIS-ASSOCIATED HYALURONAN BINDING PROTEIN, FORMS A STABLE COMPLEX WITH THE SERUM PROTEIN INTER-ALPHA-INHIBITOR", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 33, no. 23, 1 January 1994 (1994-01-01), pages 7423 - 7429, XP009004340, ISSN: 0006-2960, DOI: 10.1021/BI00189A049
LEE T H ET AL: "A NOVEL SECRETORY TUMOR NECROSIS FACTOR-INDDUCIBLE PROTEIN (TSG-6) IS A MEMBER OF THE FAMILY OF HYALURONATE BINDING PROTEINS CLOSELY RELATED TO THE ADHESION RECEPTOR CD44", THE JOURNAL OF CELL BIOLOGY : JCB, THE ROCKEFELLER UNIVERSITY PRESS, US, vol. 116, no. 2, 1 January 1992 (1992-01-01), pages 545 - 557, XP000579250, ISSN: 0021-9525, DOI: 10.1083/JCB.116.2.545
WISNIEWSKI H-G ET AL: "TSG-6, AN ARTHRITIS-ASSOCIATED HYALURONAN BINDING PROTEIN, FORMS A STABLE COMPLEX WITH THE SERUM PROTEIN INTER-ALPHA-INHIBITOR", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 33, no. 23, 1 January 1994 (1994-01-01), pages 7423 - 7429, XP009004340, ISSN: 0006-2960, DOI: 10.1021/BI00189A049
LEE T H ET AL: "A NOVEL SECRETORY TUMOR NECROSIS FACTOR-INDDUCIBLE PROTEIN (TSG-6) IS A MEMBER OF THE FAMILY OF HYALURONATE BINDING PROTEINS CLOSELY RELATED TO THE ADHESION RECEPTOR CD44", THE JOURNAL OF CELL BIOLOGY : JCB, THE ROCKEFELLER UNIVERSITY PRESS, US, vol. 116, no. 2, 1 January 1992 (1992-01-01), pages 545 - 557, XP000579250, ISSN: 0021-9525, DOI: 10.1083/JCB.116.2.545
Attorney, Agent or Firm:
NOVARTIS AG (Basel, CH)
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