Title:
COMPOSITIONS AND METHODS FOR MAKING AND USING NANOEMULSIONS
Document Type and Number:
WIPO Patent Application WO2008010788
Kind Code:
A9
Abstract:
The present invention discloses an improved nanoemulsion comprising a uniform and discrete range of very small particle nano-sized diameters. This uniformity results in improved bioavailability of incorporated compounds (i.e., pharmaceuticals or nutraceuticals) as reflected in various pharmacokinetic parameters including, but not limited to, decreased Tmax, increased Cmax, and increased AUC. The improved method of making these uniform nanoemulsions utilizes microfluidization which differs in both process and mechanics when compared to conventional milling and grinding techniques used to generate nanoparticulate compositions. Further, the improvement results, in part, from a novel step of mixing a substantially soluble compound into a heated dispersion medium. This is unlike current nanoparticulate composition methods that mix an insoluble compound with an unheated dispersion medium. Further, these nanoemulsions are observed to be bacterial-resistant and stable to extremes in both temperature and pH changes. Consequently, these nanoemulsions are expected to have a significantly prolonged shelf-life than currently available nanoemulsions.
Inventors:
NICOLOSI ROBERT (US)
WILSON THOMAS (US)
WILSON THOMAS (US)
Application Number:
PCT/US2006/026918
Publication Date:
March 06, 2008
Filing Date:
July 11, 2006
Export Citation:
Assignee:
UNIV MASSACHUSETTS LOWELL (US)
NICOLOSI ROBERT (US)
WILSON THOMAS (US)
NICOLOSI ROBERT (US)
WILSON THOMAS (US)
International Classes:
A61K9/113; A23L33/00
Download PDF:
Previous Patent: CALIBRATION METHOD FOR RECEIVE ONLY PHASED ARRAY RADAR ANTENNA
Next Patent: A STACKED LIGHT-EMITTING DEVICE AND FABRICATION THEREOF
Next Patent: A STACKED LIGHT-EMITTING DEVICE AND FABRICATION THEREOF