Title:
COMPOSITIONS AND METHODS FOR MALATE AND FUMARATE PRODUCTION
Document Type and Number:
WIPO Patent Application WO/2012/103263
Kind Code:
A3
Abstract:
The present application provides genetically modified yeast cell comprising an active malate fermentation pathway and/or an active fumarate fermentation pathway, as well as methods of using these cells to produce malate and/or fumarate.
Inventors:
FINLEY KENNETH R (US)
HURYTA JEANETTE M (US)
MASTEL BETH M (US)
MCMULLIN THOMAS W (US)
POYNTER GREGORY M (US)
RUSH BRIAN J (US)
WATTS KEVIN T (US)
FOSMER ARLENE M (US)
HURYTA JEANETTE M (US)
MASTEL BETH M (US)
MCMULLIN THOMAS W (US)
POYNTER GREGORY M (US)
RUSH BRIAN J (US)
WATTS KEVIN T (US)
FOSMER ARLENE M (US)
Application Number:
PCT/US2012/022615
Publication Date:
October 04, 2012
Filing Date:
January 25, 2012
Export Citation:
Assignee:
FINLEY KENNETH R (US)
HURYTA JEANETTE M (US)
MASTEL BETH M (US)
MCMULLIN THOMAS W (US)
POYNTER GREGORY M (US)
RUSH BRIAN J (US)
WATTS KEVIN T (US)
FOSMER ARLENE M (US)
HURYTA JEANETTE M (US)
MASTEL BETH M (US)
MCMULLIN THOMAS W (US)
POYNTER GREGORY M (US)
RUSH BRIAN J (US)
WATTS KEVIN T (US)
FOSMER ARLENE M (US)
International Classes:
C12P7/46; C12N1/15; C12N9/00; C12N9/04; C12N9/98
Domestic Patent References:
| WO2002010425A2 | 2002-02-07 |
Foreign References:
| US20080090273A1 | 2008-04-17 | |||
| US20090191599A1 | 2009-07-30 | |||
| US20040199940A1 | 2004-10-07 | |||
| US20100009419A1 | 2010-01-14 | |||
| US20100184171A1 | 2010-07-22 | |||
| US20080009041A1 | 2008-01-10 | |||
| US5876983A | 1999-03-02 | |||
| US20100280803A1 | 2010-11-04 | |||
| US20100120105A1 | 2010-05-13 | |||
| US20080148432A1 | 2008-06-19 | |||
| US20070027309A1 | 2007-02-01 | |||
| US20070118916A1 | 2007-05-24 |
Other References:
DATABASE UNIPROT 28 July 2009 (2009-07-28), "The Genolevures Consortium. Comparative genomics of protoploid Saccharomycetaceae.", retrieved from http://www.uniprot.org/uniproUC5DSS7.txt?version=3 accession no. 5DSS7_ ZYGRC.
DATABASE GENBANK 14 January 2010 (2010-01-14), SOUCI ET AL.: "Zygosaccharomyces rouxii strain CBS732 chromosome C complete sequence.", retrieved from http://www.ncbi.nlm.nih.gov/nuccore/CU928175 accession no. U928175.1.
SIGMA-ALDRICH.: "Pentose Phosphate Pathway.", PENTOSE PHOSPHATE PATHWAY., 5 July 2012 (2012-07-05), Retrieved from the Internet
THOMAS ET AL.: "Identification of the structural gene for glucose-6-phosphate dehydrogenase in yeast. Inactivation leads to a nutritional requirement for organic sulfur.", EMBO JOURNAL, vol. 10, 1991, pages 547 - 553
DATABASE UNIPROT 20 March 2007 (2007-03-20), ZHANG ET AL.: "Cloning and characterization of the partial gene CgZWF encoding glucose 6- phosphate dehydrogenase from Candida glycerinogenes.", retrieved from http://www.uniprot.org/uniproUA3FFK8.txt?version=13 accession no. 3FFK8 CANGY
DATABASE GENBANK 11 February 2007 (2007-02-11), ZHANG ET AL.: "Candida glycerinogenes glucose 6-phosphate dehydrogenase gene", retrieved from http://www.ncbi.nlm.nih.gov/nuccore/EF373653 accession no. F373653.
DATABASE GENBANK 14 January 2010 (2010-01-14), SOUCI ET AL.: "Zygosaccharomyces rouxii strain CBS732 chromosome C complete sequence.", retrieved from http://www.ncbi.nlm.nih.gov/nuccore/CU928175 accession no. U928175.1.
SIGMA-ALDRICH.: "Pentose Phosphate Pathway.", PENTOSE PHOSPHATE PATHWAY., 5 July 2012 (2012-07-05), Retrieved from the Internet
THOMAS ET AL.: "Identification of the structural gene for glucose-6-phosphate dehydrogenase in yeast. Inactivation leads to a nutritional requirement for organic sulfur.", EMBO JOURNAL, vol. 10, 1991, pages 547 - 553
DATABASE UNIPROT 20 March 2007 (2007-03-20), ZHANG ET AL.: "Cloning and characterization of the partial gene CgZWF encoding glucose 6- phosphate dehydrogenase from Candida glycerinogenes.", retrieved from http://www.uniprot.org/uniproUA3FFK8.txt?version=13 accession no. 3FFK8 CANGY
DATABASE GENBANK 11 February 2007 (2007-02-11), ZHANG ET AL.: "Candida glycerinogenes glucose 6-phosphate dehydrogenase gene", retrieved from http://www.ncbi.nlm.nih.gov/nuccore/EF373653 accession no. F373653.
Attorney, Agent or Firm:
MORRIS, Patrick D. (P.O. Box 1208Seattle, Washington, US)
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