Title:
COMPOSITIONS AND METHODS FOR MODELING BACILLUS SUBTILIS METABOLISM
Document Type and Number:
WIPO Patent Application WO2003081207
Kind Code:
A3
Abstract:
The invention provides an in silico model for determining a Bacillus subtilis physiological function. The model includes a data structure relating a plurality of B. subtilis reactants to a plurality of B. subtilis reactions, a constraint set for the plurality of B. subtilis reactions, and commands for determining a distribution of flux through the reactions that is predictive of a B. subtilis physiological function. A model of the invention can further include a gene database containing information characterizing the associated gene or genes. A regulated B. subtilis reaction can be represented in a model of the invention by including a variable constraint for the regulated reaction. The invention further provides methods for making an in silico B. subtilis model and methods for determining a B. subtilis physiological function using a model of the invention.
Inventors:
PARK SUNG M (US)
SCHILLING CHRISTOPHE H (US)
PALSSON BERNHARD O (US)
SCHILLING CHRISTOPHE H (US)
PALSSON BERNHARD O (US)
Application Number:
PCT/US2003/008326
Publication Date:
July 01, 2004
Filing Date:
March 18, 2003
Export Citation:
Assignee:
GENOMATICA INC (US)
PARK SUNG M (US)
SCHILLING CHRISTOPHE H (US)
PALSSON BERNHARD O (US)
PARK SUNG M (US)
SCHILLING CHRISTOPHE H (US)
PALSSON BERNHARD O (US)
International Classes:
G16B5/10; G06F19/00; G16B50/00; (IPC1-7): G01N33/48; G01N31/00; G06F19/00
Other References:
GOTO ET AL: "Ligand: Chemical database for enzyme reactions", BIOINFORMATICS, vol. 14, no. 7, 1998, pages 591 - 599, XP002972649
OGATA ET AL.: "KEGG: Kyoto Encyclopedia of genes and genomes", NUCLEIC ACID RESEARCH, vol. 27, no. 1, 1999, pages 29 - 34, XP002964856
OGATA ET AL.: "KEGG: Kyoto Encyclopedia of genes and genomes", NUCLEIC ACID RESEARCH, vol. 27, no. 1, 1999, pages 29 - 34, XP002964856
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