Title:
COMPOSITIONS AND METHODS FOR MODULATION OF TARGET NUCLEIC ACIDS
Document Type and Number:
WIPO Patent Application WO/2014/205451
Kind Code:
A3
Abstract:
The present disclosure pertains generally to chemically-modified oligonucleotides for use in research, diagnostics, and/or therapeutics. In certain embodiments, the present disclosure describes compounds and methods for the modulation of a target nucleic acid. In certain embodiments, the present disclosure describes compounds and methods for the modulation of Apoliprotein C-III expression.
Inventors:
PRAKASH THAZHA P (US)
LIMA WALTER F (US)
KINBERGER GARTH A (US)
MURRAY HEATHER (US)
SWAYZE ERIC E (US)
CROOKE STANLEY T (US)
LIMA WALTER F (US)
KINBERGER GARTH A (US)
MURRAY HEATHER (US)
SWAYZE ERIC E (US)
CROOKE STANLEY T (US)
Application Number:
PCT/US2014/043731
Publication Date:
February 19, 2015
Filing Date:
June 23, 2014
Export Citation:
Assignee:
ISIS PHARMACEUTICALS INC (US)
International Classes:
C12N15/113
Domestic Patent References:
| WO2012177947A2 | 2012-12-27 | |||
| WO2010083615A1 | 2010-07-29 |
Foreign References:
| US20120122958A1 | 2012-05-17 |
Other References:
CZECH ET AL.: "RNAi-based therapeutic strategies for metabolic disease", NATURE REVIEWS ENDOCRINOLOGY, vol. 7, 19 April 2011 (2011-04-19), pages 473 - 484, XP055302327
KASSIM ET AL.: "Gene therapy for dyslipidemia: a review of gene replacement and gene inhibition strategies", CLINICAL LIPIDOLOGY, vol. 5, no. 6, 1 December 2010 (2010-12-01), pages 793 - 809, XP008182607
KASSIM ET AL.: "Gene therapy for dyslipidemia: a review of gene replacement and gene inhibition strategies", CLINICAL LIPIDOLOGY, vol. 5, no. 6, 1 December 2010 (2010-12-01), pages 793 - 809, XP008182607
Attorney, Agent or Firm:
SCARR, Rebecca et al. (2275 Deming Way Suite 31, Middleton WI, US)
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