Title:
COMPOSITIONS AND METHODS FOR NEURONAL DIFFERENTIATION OF CELLS
Document Type and Number:
WIPO Patent Application WO/2016/090408
Kind Code:
A8
Abstract:
This invention relates to compositions and methods for enhanced differentiation of cells towards a neuronal phenotype. Neuronal cells produced using the compositions and methods may be used in the study of neurological diseases and disorders, for drug screening and for therapeutic purposes. The invention provides a method for producing a neuron comprising inducing neuronal differentiation of a cell, wherein neuronal differentiation in said cell is induced by inhibition of Small Mothers Against Decapentaplegic (SMAD) signaling and nitric oxide synthase (NOS) in said cell.
Inventors:
SUE CAROLYN (AU)
GAO STEVEN (AU)
BLAIR NICHOLAS (AU)
GAO STEVEN (AU)
BLAIR NICHOLAS (AU)
Application Number:
PCT/AU2015/000739
Publication Date:
July 20, 2017
Filing Date:
December 08, 2015
Export Citation:
Assignee:
NORTHERN SYDNEY LOCAL HEALTH DISTR (AU)
International Classes:
C12N5/079; C12N5/071; C12Q1/02
Attorney, Agent or Firm:
SPRUSON & FERGUSON (AU)
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