Title:
COMPOSITIONS AND METHODS FOR NON-ALCOHOLIC STEATOHEPATITIS (NASH)
Document Type and Number:
WIPO Patent Application WO/2021/142347
Kind Code:
A1
Abstract:
The present disclosure is in the field of pharmaceutical compositions suitable for the treatment of NAFLD or NASH in mammals. The disclosure provides novel compositions comprising non-pathogenic fecal microbes for treating non-alcoholic steatohepatitis (NASH) and related diseases. The disclosure also provides methods for treating a subject with the compositions disclosed herein.
Inventors:
SMITH MARK (US)
KASSAM ZAIN (US)
KASSAM ZAIN (US)
Application Number:
PCT/US2021/012812
Publication Date:
July 15, 2021
Filing Date:
January 08, 2021
Export Citation:
Assignee:
FINCH THERAPEUTICS HOLDINGS LLC (US)
International Classes:
A61K35/74; A61P1/16
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CHALASANI, NAMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASESAMERICAN COLLEGE OF GASTROENTEROLOGYAMERICAN GASTROENTEROLOGICAL A: "The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline", HEPATOLOGY, vol. 55, no. 6, 2012, pages 2005 - 2023, XP055624306, DOI: 10.1002/hep.25762
REEDER, S.SIRLIN, C., MAGN RESON IMAGING CLIN N AM, vol. 18, no. 3, 2010, pages 337 - 357
KOLODZIEJCZYK, A. ET AL., EMBO MOL MED, vol. 11, no. 2, 2019, pages 1 - 13
MA, H. ET AL., BMC GASTROENTEROL, vol. 3, no. 13, 2013, pages 1 - 6
SVEDLUND ET AL., DIG. DIS. SCI., vol. 33, no. 2, 1988, pages 129 - 34
ZHOU DA ET AL: "Total fecal microbiota transplantation alleviates high-fat diet-induced steatohepatitis in mice via beneficial regulation of gut microbiota", SCIENTIFIC REPORTS, vol. 7, no. 1, 8 May 2017 (2017-05-08), pages 1 - 11, XP055777414, Retrieved from the Internet
CHU, N. ET AL.: "Profiling living bacteria informs preparation of fecal microbiota transplantations", PLOS ONE, vol. 12, no. 1, 2017, pages 1 - 16, XP055619403, DOI: 10.1371/journal.pone.0170922
GEVERS ET AL.: "The treatment-naive microbiomes in new-onset Crohn's disease", CELL HOST & MICROBE, vol. 15, no. 3, 2014, pages 382 - 92
GEVERS ET AL., CELL HOST & MICROBE, vol. 15, no. 3, 2014, pages 382 - 92
CHU ET AL., PLOS ONE, vol. 12, no. 1, 2017, pages 1 - 16
STOCKS, CYTOMETRY A., vol. 61, no. 2, October 2004 (2004-10-01), pages 189 - 95
CANGELOSIMESCHEKE, APPL ENVIRON MICROBIOL, vol. 80, no. 19, October 2014 (2014-10-01), pages 5884 - 5891
SHANNONWEAVER: "The mathematical theory of communication", 1949, THE UNIVERSITY OF ILLINOIS PRESS, pages: 117
OTT ET AL., GASTROENTEROLOGY, vol. 152, 2017, pages 799 - 911
LI ET AL., AAPS PHARMSCITECH, vol. 3, no. 4, 2002, pages 1 - 9
CHALASANI ET AL., HEPATOLOGY, vol. 1, no. 67, 2018, pages 328 - 357
CHALASANI, NAMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASESAMERICAN COLLEGE OF GASTROENTEROLOGYAMERICAN GASTROENTEROLOGICAL A: "The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline", HEPATOLOGY, vol. 55, no. 6, 2012, pages 2005 - 2023, XP055624306, DOI: 10.1002/hep.25762
REEDER, S.SIRLIN, C., MAGN RESON IMAGING CLIN N AM, vol. 18, no. 3, 2010, pages 337 - 357
KOLODZIEJCZYK, A. ET AL., EMBO MOL MED, vol. 11, no. 2, 2019, pages 1 - 13
MA, H. ET AL., BMC GASTROENTEROL, vol. 3, no. 13, 2013, pages 1 - 6
SVEDLUND ET AL., DIG. DIS. SCI., vol. 33, no. 2, 1988, pages 129 - 34
Attorney, Agent or Firm:
MARSH, David et al. (US)
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